N-(5-(2-aminophenylcarbamoyl)pentyl)-3-methyl-4-(5-pyrimidinyl)-benzamide | 1255951-54-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-(5-(2-aminophenylcarbamoyl)pentyl)-3-methyl-4-(5-pyrimidinyl)-benzamide
• 英文别名: N-[6-(2-aminoanilino)-6-oxohexyl]-3-methyl-4-pyrimidin-5-ylbenzamide
• CAS: 1255951-54-2
• 化学式: C₂₄H₂₇N₅O₂
• 分子量: 417.511
• InChiKey: NDOQOYMXQCHYNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  110
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• ISOINDOLINONE DERIVATIVES, PREPARATION METHOD THEREOF AND A PHARMACEUTICAL COMPOSITION COMPRISING SAME
  申请人：Heo Jung Nyoung

  公开号：US20120065396A1

  公开（公告）日：2012-03-15

  The present invention relates to an amide compound or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutical composition comprising the same. The inventive amide compound facilitates bone formation and inhibits bone loss, and is therefore useful for preventing and treating bone disorders such as osteoporosis, osteodystrophy, bone fracture, periodontal disease, Paget's disease, bone metastasis, and rheumatoid arthritis.

  本发明涉及一种酰胺化合物或其药学上可接受的盐，其制备方法以及包含它的制药组合物。本发明的酰胺化合物促进骨形成并抑制骨丢失，因此可用于预防和治疗骨疾病，如骨质疏松症、骨发育不良、骨折、牙周疾病、Paget病、骨转移和类风湿性关节炎。
• Fluorinated Silyethynyl Pentacene Compounds and Compositions and Methods of Making and Using the Same
  申请人：Clough Robert Steven

  公开号：US20120061620A1

  公开（公告）日：2012-03-15

  Fluorinated silylethynyl pentacenes and compositions containing fluorinated silylethynyl pentacenes are disclosed. Methods of making and using fluorinated silylethynyl pentacenes and compositions containing fluorinated silylethynyl pentacenes are also disclosed.

  本文介绍了氟代硅基乙炔基五环芘和含有氟代硅基乙炔基五环芘的组合物。还揭示了制备和使用氟代硅基乙炔基五环芘及含有氟代硅基乙炔基五环芘的组合物的方法。
• AMIDE COMPOUND, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
  申请人：Korea Research Institute Of Chemical Technology

  公开号：EP2429987A2

  公开（公告）日：2012-03-21
• FLUORINATED SILYLETHYNYL PENTACENE COMPOUNDS AND COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME
  申请人：3M Innovative Properties Co.

  公开号：EP2435446B1

  公开（公告）日：2016-11-30
• US8716326B2
  申请人：——

  公开号：US8716326B2

  公开（公告）日：2014-05-06