2-(3-Fluoro-phenyl)-propionamide | 65487-31-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-Fluoro-phenyl)-propionamide
• 英文别名: 2-(3-Fluorophenyl)propanamide
• CAS: 65487-31-2
• 化学式: C₉H₁₀FNO
• 分子量: 167.183
• InChiKey: MLCPOIXUBJUVGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  氯乙酰氯 、 2-(3-Fluoro-phenyl)-propionamide 生成 2-[4-(2-Chloro-acetyl)-3-fluoro-phenyl]-propionamide
  参考文献：
  名称：

  MURO TOMIO; NAKAO TOHRU; OGAWA KIYOSHI; MARUYAMA YUTAKA; ANAMI KORETAKE, YAKUGAKU DZASSI, YAKUGAKI ZASSNI, J. PHARM. SOS. JAR., 1977, 97, HO 8, 83+

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(3-氟苯基)丙酸 生成 2-(3-Fluoro-phenyl)-propionamide
  参考文献：
  名称：

  MURO TOMIO; NAKAO TOHRU; OGAWA KIYOSHI; MARUYAMA YUTAKA; ANAMI KORETAKE, YAKUGAKU DZASSI, YAKUGAKI ZASSNI, J. PHARM. SOS. JAR., 1977, 97, HO 8, 83+

  摘要：

  DOI：

文献信息

• Anticonvulsant and central nervous system-active bis(fluorophenyl)alkylamides
  申请人：NPS PHARMACEUTICALS, INC.

  公开号：EP1640359A2

  公开（公告）日：2006-03-29

  Bis(Fluorophenyl)alkylamides have been chemically synthesized which possess beneficial pharmacological properties (e.g., anticonvulsant activity) useful for the treatment of neurological disease or disorders, such as, for example, epilepsy, convulsions, and seizure disorders. The preferred compounds of the invention also cause little sedation and have high therapeutic and protective indices in animal models of epilepsy. These compounds further possess long pharmacologic half-lives, which, in practical clinical therapeutic application, should translate into once-a-day dosing, of great benefit to patients suffering from these diseases and/or disorders. These compounds may also be of further clinical utility in the treatment of other diseases and disorders of the central and peripheral nervous systems, or diseases or disorders affected by them, including, but not limited to, spasticity, skeletal muscle spasms and pain, restless leg syndrome, anxiety and stress, and bipolar disorder.

  双(氟苯基)烷基酰胺已被化学合成，具有有益的药理特性（如抗惊厥活性），可用于治疗神经系统疾病或紊乱，如癫痫、抽搐和癫痫发作紊乱等。本发明的优选化合物也几乎不会引起镇静，在癫痫动物模型中具有较高的治疗和保护指数。这些化合物还具有较长的药理半衰期，在实际临床治疗应用中，可实现一天一次给药，对这些疾病和/或失调患者大有裨益。这些化合物在治疗中枢和周围神经系统的其他疾病和失调，或受其影响的疾病或失调，包括但不限于痉挛、骨骼肌痉挛和疼痛、不安腿综合征、焦虑和压力，以及躁郁症等方面，也可能具有进一步的临床效用。
• Method of treating ocular inflammatory and angiogenesis-related disorders of the posterior segment of the eye using an amide derivative of flurbiprofen or ketorolac
  申请人：Alcon, Inc.

  公开号：US20020183376A1

  公开（公告）日：2002-12-05

  The topical use of certain flurbiprofen amide derivatives and ketorolac amide derivatives to treat ophthalmic angiogenesis-related and inflammatory disorders of the posterior segment of the eye is disclosed.

  本发明公开了某些氟比洛芬酰胺衍生物和酮咯酸酰胺衍生物的局部使用方法，用于治疗眼科血管生成相关疾病和眼球后段炎症性疾病。
• [EN] METHOD OF TREATING OCULAR INFLAMMATORY AND ANGIOGENESIS-RELATED DISORDERS OF THE POSTERIOR SEGMENT OF THE EYE USING AN AMIDE DERIVATIVE OF FLURBIPROFEN OR KETOROLAC<br/>[FR] PROCEDE PERMETTANT DE TRAITER LES TROUBLES INFLAMMATOIRES OCULAIRES ET LES TROUBLES LIES A L'ANGIOGENESE DU SEGMENT POSTERIEUR DE L'OEIL A L'AIDE D'UN DERIVE AMIDE DE FLURBIPROFEN OU DE KETOROLAC
  申请人：ALCON INC

  公开号：WO2002078681A2

  公开（公告）日：2002-10-10

  The topical use of certain flurbiprofen amide derivatives and ketorolac amide derivatives to treat ophthalmic angiogenesis-related and inflammatory disorders of the posterior segment of the eye is disclosed.

  本发明公开了局部使用某些氟比洛芬酰胺衍生物和酮咯酸酰胺衍生物来治疗眼科血管生成相关和眼后节炎症性疾病的用途。
• ANTICONVULSANT AND CENTRAL NERVOUS SYSTEM-ACTIVE BIS(FLUOROPHENYL)ALKYLAMIDES
  申请人：NPS PHARMACEUTICALS, INC.

  公开号：EP1042275A1

  公开（公告）日：2000-10-11
• FORMULATIONS CONTAINING AMIDE DERIVATIVES OF CARBOXYLIC ACID NSAIDS FOR TOPICAL ADMINISTRATION TO THE EYE
  申请人：ALCON INC.

  公开号：EP2012767A2

  公开（公告）日：2009-01-14