5-丁基-5-乙基巴比土酸钠 | 35763-44-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 5-丁基-5-乙基巴比土酸钠
• CAS: 35763-44-1
• 化学式: C10H16N2NaO3
• 分子量: 235.24
• InChiKey: QPXULTOHMFSFKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.56
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  75.3
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2933540000

文献信息

• Method of conjugating aminothiol containing molecules to vehicles
  申请人：D'Amico C. Derin

  公开号：US20060199812A1

  公开（公告）日：2006-09-07

  The present invention relates to a novel chemical process that provides novel vehicle derivatives that are exceptional 1,2- or 1,3-aminothiol specific reagents for conjugation to unprotected targeted compounds (e.g., polypeptides, peptides, or organic compounds) having or modified to have a 1,2- or 1,3 aminothiol group. The invention further relates to the methods of using novel water-soluble polymer derivatives and conjugates thereof.

  本发明涉及一种新型化学过程，提供了新型车载衍生物，这些衍生物是杰出的1,2-或1,3-氨基硫醇特异性试剂，可用于与未保护的靶向化合物（例如多肽，肽或有1,2-或1,3-氨基硫醇基团的有机化合物）结合。本发明还涉及使用新型水溶性聚合物衍生物及其共轭物的方法。
• Gas-filled microvesicles composition for contrast imaging
  申请人：BRACCO SUISSE S.A.

  公开号：US10076580B2

  公开（公告）日：2018-09-18

  The present invention relates to a new composition comprising gas-filled microvesicles for contrast imaging which are particularly suitable for providing an effective echo response to at least two selected ultrasound waves having different frequencies. Said composition preferably comprises at least two different preparations of gas-filled microvesicles having respective peaks of non-linear echographic response differing by at least 2 MHz to each other, and preferably have respective size distributions with different median sizes. In particular, said preparations preferably have size distributions with respective DV50 values differing from each other by at least 0.5 μm, more preferably at least 1.0 μm. Alternatively, said composition has a volume size distribution showing a value of Bowley skewness of 0.16 or higher. According to a preferred embodiment, at least 95% of the total volume of gas contained in said microvesicles, calculated on the population of microvesicles up to a diameter of 10 μm, is contained in microvesicles having a diameter of 8 micron or less.

  本发明涉及一种新的组合物，该组合物包含用于造影的充气微囊，特别适用于对至少两种频率不同的选定超声波提供有效的回声响应。所述组合物最好包含至少两种不同的充气微囊制剂，它们各自的非线性回声响应峰值相差至少 2 兆赫，并且最好具有不同中值尺寸的各自尺寸分布。特别是，所述制剂最好具有各自 DV50 值相差至少 0.5 μm，更优选至少 1.0 μm 的粒度分布。或者，所述组合物的体积分布显示出 0.16 或更高的鲍利偏度值。根据一个优选的实施方案，以直径不超过 10 μm 的微囊群计算，所述微囊所含气体总体积的至少 95% 包含在直径为 8 微米或更小的微囊中。
• LIPOSOMAL ASSEMBLY FOR THERAPEUTIC AND/OR DIAGNOSTIC USE
  申请人：BRACCO RESEARCH S.A.

  公开号：EP1750671A1

  公开（公告）日：2007-02-14
• GAS-FILLED MICROVESICLES COMPOSITION FOR CONTRAST IMAGING
  申请人：Bracco Suisse SA

  公开号：EP1784228B1

  公开（公告）日：2016-10-05
• METHOD OF CONJUGATING AMINOTHIOL CONTAINING MOLECULES TO VEHICLES
  申请人：Amgen Inc.

  公开号：EP1848463A2

  公开（公告）日：2007-10-31