Pr(i)HNC(O)CH2P(O)(Ph)2 | 474900-37-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Pr(i)HNC(O)CH2P(O)(Ph)2
• CAS: 474900-37-3
• 化学式: C₁₇H₂₀NO₂P
• 分子量: 301.325
• InChiKey: DXVSFNLPFJQQEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.53
• 重原子数：
  21.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  46.17
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  [Bz2N(H)B12H10O(CH2)4] 、 Pr(i)HNC(O)CH2P(O)(Ph)2 在 NaH 作用下， 以 四氢呋喃 为溶剂， 以51%的产率得到K[Bz2N(H)B12H10O(CH2)4N(Pr(i))C(O)CH2P(O)(Ph)2]
  参考文献：
  名称：

  Synthesis of [B12H12]2− based extractants and their application for the treatment of nuclear wastes

  摘要：

  Several closo-hydroborates bearing phosphite oxide, phosphine oxide or CMPO (carbamoylmethylphosphine oxide) groups, Cs[(Ph2P(O))(2)N(H)B12H11] (1), K[Ph2P(O)CH2C(O)N(H)(2)B12H11] (2), Na[Bz(2)N(H)B12H10OCH2CH2OCH2CH2P(O)(OBu)(2)] (5), Na[Bz(2)N(H)B12H10O(CH2)(4)N(R)C(O)CH2P(O)(Ph)(2)] (9, R=Pr-i; 10, R= Octyl), Na[Bz(2)N(H)B12H10OCH2CH2OCH2CH2N(Bu-i)C(O)CH2P(O)(Ph)(2)](-) (11) were synthesised employing novel neutral bipolar intermediates [Bz(2)N(H)B12H10O(CH2)(4)] (3) and [Bz(2)N(H)B12H10O(CH2CH2)(2)O] (4) as useful synthons. All new compounds were characterised by NMR spectroscopy and mass spectrometry techniques. Their abilities to extract selectively the radionuclides Am-241 and Eu-152 from nuclear waste solutions were investigated using a liquid-liquid extraction technique. Promising results were obtained with compound 10, which exhibits enhanced hydrophobicity and solubility in organic extraction solvent. (C) 2002 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-328x(02)01540-1
• 作为产物：
  描述：

  异丙胺 、 p-nitrophenyl diphenylphosphorylacetate 以92%的产率得到Pr(i)HNC(O)CH2P(O)(Ph)2
  参考文献：
  名称：

  Synthesis of [B12H12]2− based extractants and their application for the treatment of nuclear wastes

  摘要：

  Several closo-hydroborates bearing phosphite oxide, phosphine oxide or CMPO (carbamoylmethylphosphine oxide) groups, Cs[(Ph2P(O))(2)N(H)B12H11] (1), K[Ph2P(O)CH2C(O)N(H)(2)B12H11] (2), Na[Bz(2)N(H)B12H10OCH2CH2OCH2CH2P(O)(OBu)(2)] (5), Na[Bz(2)N(H)B12H10O(CH2)(4)N(R)C(O)CH2P(O)(Ph)(2)] (9, R=Pr-i; 10, R= Octyl), Na[Bz(2)N(H)B12H10OCH2CH2OCH2CH2N(Bu-i)C(O)CH2P(O)(Ph)(2)](-) (11) were synthesised employing novel neutral bipolar intermediates [Bz(2)N(H)B12H10O(CH2)(4)] (3) and [Bz(2)N(H)B12H10O(CH2CH2)(2)O] (4) as useful synthons. All new compounds were characterised by NMR spectroscopy and mass spectrometry techniques. Their abilities to extract selectively the radionuclides Am-241 and Eu-152 from nuclear waste solutions were investigated using a liquid-liquid extraction technique. Promising results were obtained with compound 10, which exhibits enhanced hydrophobicity and solubility in organic extraction solvent. (C) 2002 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-328x(02)01540-1