1-(4-methylpyridin-2-yl)-3,5-dimethylpyrazole | 1174635-81-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-(4-methylpyridin-2-yl)-3,5-dimethylpyrazole
• 英文别名: 2-(3,5-dimethylpyrazol-1-yl)-4-methylpyridine
• CAS: 1174635-81-4
• 化学式: C₁₁H₁₃N₃
• 分子量: 187.244
• InChiKey: JESIVANAMNCKMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-hydrazino-4-methylpyridine hydrochloride 、 乙酰丙酮 在 sodium hydroxide 作用下， 以 水 为溶剂， 以80%的产率得到1-(4-methylpyridin-2-yl)-3,5-dimethylpyrazole
  参考文献：
  名称：

  SKIN WHITENING AGENT AND EXTERNAL PREPARATION FOR THE SKIN

  摘要：

  公开号：

  EP2250998B1

文献信息

• [EN] METAL COMPLEXES FOR USE AS DOPANTS AND OTHER USES<br/>[FR] COMPLEXES MÉTALLIQUES DESTINÉS À UNE UTILISATION COMME DOPANTS ET AUTRES UTILISATIONS
  申请人：ECOLE POLYTECH

  公开号：WO2012114316A1

  公开（公告）日：2012-08-30

  The invention relates to electrochemical devices comprising complexes of cobalt comprising at least one ligand with a 5- or six membered, N- containing heteroring. The complex are useful as p- and n- dopants, as over of electrochemical devices, in particular in organic semiconductors. The complexes are further useful as over- discharge prevention and overvoltage protection agents.

  该发明涉及包含至少一个含有5-或六元N杂环的配体的钴络合物的电化学器件。这些配合物可用作p-和n-掺杂剂，用于电化学器件，特别是有机半导体器件。这些络合物还可用作过放电预防和过电压保护剂。
• Derivatives of 8-substituted xanthines
  申请人：Wang Guoquan

  公开号：US20070249598A1

  公开（公告）日：2007-10-25

  The present invention provides compounds and pharmaceutical compositions that are selective antagonists of A 2B adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.

  本发明提供了选择性拮抗A2B腺苷受体（ARs）的化合物和药物组合物。这些化合物和组合物可用作药物制剂。
• Organic Compounds
  申请人：Shaw Duncan

  公开号：US20100210641A1

  公开（公告）日：2010-08-19

  Compounds of formula I: in free or salt or solvate form, where R 1 , R 2 , R 3 and R 20 have the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described. These compounds are useful for the treatment of inflammatory or obstructive airways diseases such as pulmonary hypertension, pulmonary fibrosis, liver fibrosis, cancer, muscle diseases such as muscle atrophies and muscle dystrophies, and systemic skeletal disorders such as osteoporosis.

  式I的化合物：以自由或盐或溶剂形式存在，其中R1，R2，R3和R20具有规范中指定的含义，可用于治疗由ALK-5和/或ALK-4受体介导的疾病。还描述了含有这些化合物的制药组合物和制备这些化合物的方法。这些化合物对于治疗炎症或阻塞性呼吸道疾病，如肺动脉高压，肺纤维化，肝纤维化，癌症，肌肉疾病，如肌肉萎缩和肌肉营养不良，以及全身性骨骼疾病，如骨质疏松症非常有用。
• Whitening agent and skin external preparation
  申请人：Hanyu Naoto

  公开号：US08563552B2

  公开（公告）日：2013-10-22

  The present invention provides a compound having an excellent inhibitory action on melanin production and being useful as a whitening agent, and a skin external preparation containing the compound. The whitening agent of the present invention comprises, as an active ingredient, a compound represented by formula (1) or a pharmacologically acceptable salt thereof: wherein X1, X2, and X3 are each CR2 or N; R1, R2, and R3 are each H, C1-6 alkyl, C1-6 alkoxy, SH, OH, or NRbRc, wherein Rb and Rc are each H, C1-6 alkyl, or hydroxy-C1-6 alkyl, or NRbRc forms a saturated or unsaturated 5- or 6-membered hetero ring; and B is a substituted or unsubstituted pyrazole, imidazole, pyridine, or piperidine; with the proviso that at least one of R1, R3, R4, and R6 is a group other than C1-3 alkyl in the case where X1═X2═Y1═N and X3═CR2.

  本发明提供了一种在黑色素生成抑制方面具有优异作用并可用作美白剂的化合物，以及含有该化合物的皮肤外用制剂。本发明的美白剂包含以下化合物作为活性成分：式（1）或其药理学上可接受的盐：其中，X1、X2和X3分别为CR2或N；R1、R2和R3分别为H、C1-6烷基、C1-6烷氧基、SH、OH或NRbRc，其中，Rb和Rc分别为H、C1-6烷基或羟基-C1-6烷基，或NRbRc形成饱和或不饱和的5-或6元杂环；B为取代或未取代的吡唑、咪唑、吡啶或哌啶；在X1═X2═Y1═N且X3═CR2的情况下，R1、R3、R4和R6中至少有一个为C1-3烷基以外的基团。
• METAL COMPLEXES FOR USE AS DOPANTS AND OTHER USES
  申请人：Burschka Julian

  公开号：US20130330632A1

  公开（公告）日：2013-12-12

  The invention relates to electrochemical devices comprising complexes of cobalt comprising at least one ligand with a 5- or six membered, N-containing heteroring. The complex are useful as p- and n-dopants, as over of electrochemical devices, in particular in organic semiconductors. The complexes are further useful as over-discharge prevention and overvoltage protection agents.

  本发明涉及包含钴配合物的电化学装置，该配合物包含至少一个含有5或6个成员的N-含杂环的配体。该配合物可用作p-和n-掺杂剂，用于电化学装置，特别是有机半导体器件。该配合物还可用作过放电预防和过电压保护剂。