Octahydrocyclopenta[b]pyrrole hydrochloride | 2137857-51-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: Octahydrocyclopenta[b]pyrrole hydrochloride
• 英文别名: 1,2,3,3a,4,5,6,6a-octahydrocyclopenta[b]pyrrole;hydrochloride
• CAS: 2137857-51-1
• 化学式: C7H14ClN
• 分子量: 147.64
• InChiKey: PQAJNJOXKMQYSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.57
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,6-二溴吡啶 、 Octahydrocyclopenta[b]pyrrole hydrochloride 在 potassium phosphate 作用下， 以 1,4-二氧六环 为溶剂， 生成 1-(6-bromopyridin-2-yl)-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole
  参考文献：
  名称：

  HETEROCYCLIC COMPOUNDS, PREPARATION METHODS AND USES THEREOF

  摘要：

  Provided herein are novel compounds, for example, compounds having a Formula (I), a prodrug thereof, or a pharmaceutically acceptable salt thereof. Also provided herein are pharmaceutical compositions comprising a compound having a Formula (I), a prodrug thereof, or a pharmaceutically acceptable salt thereof, methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KIF18A in a cell, and/or in treating various cancers associated with KIF18A protein.

  公开号：

  WO2024109923A1
• 作为产物：
  描述：

  2-(3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrol-1-yl)-2-phenylethanol 在 氢气 、 palladium(II) hydroxide 、 盐酸 作用下， 以 异丙醇 、 1,4-二氧六环 、 水 为溶剂， 生成 Octahydrocyclopenta[b]pyrrole hydrochloride
  参考文献：
  名称：

  HETEROCYCLIC COMPOUNDS, PREPARATION METHODS AND USES THEREOF

  摘要：

  Provided herein are novel compounds, for example, compounds having a Formula (I), a prodrug thereof, or a pharmaceutically acceptable salt thereof. Also provided herein are pharmaceutical compositions comprising a compound having a Formula (I), a prodrug thereof, or a pharmaceutically acceptable salt thereof, methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KIF18A in a cell, and/or in treating various cancers associated with KIF18A protein.

  公开号：

  WO2024109923A1

文献信息

• [EN] TRIAZOLOPYRIDINE COMPOUNDS<br/>[FR] COMPOSÉS DE TRIAZOLOPYRIDINE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2012163724A1

  公开（公告）日：2012-12-06

  The present invention relates to the use of novel triazolopyridine derivatives of formula I: wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.

  本发明涉及使用以下式I的新型三唑吡啶衍生物：其中所有变量取代基的定义如本文所述，这些衍生物是SYK抑制剂，可用于治疗自身免疫和炎症性疾病。