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4'-(羟基甲基)联苯-3-羧酸 | 773872-69-8

中文名称
4'-(羟基甲基)联苯-3-羧酸
中文别名
——
英文名称
4'-(Hydroxymethyl)-[1,1'-biphenyl]-3-carboxylic acid
英文别名
3-[4-(hydroxymethyl)phenyl]benzoic acid
4'-(羟基甲基)联苯-3-羧酸化学式
CAS
773872-69-8
化学式
C14H12O3
mdl
——
分子量
228.24
InChiKey
ZOCJZYHNQJDOGC-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    2.7
  • 重原子数:
    17
  • 可旋转键数:
    3
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.07
  • 拓扑面积:
    57.5
  • 氢给体数:
    2
  • 氢受体数:
    3

文献信息

  • Biphenyl Esters, Their Production and Their Use in the Manufacture of Plasticizers
    申请人:ExxonMobil Chemical Patents Inc.
    公开号:US20150361027A1
    公开(公告)日:2015-12-17
    A biphenyl diester useful as a plasticizer having the formula (I): wherein R 1 is an alkyl group having 5 to 15 carbon atoms and R 2 is a methyl group or a phenyl group.
    一种作为增塑剂有用的联苯二酯,化学式为(I):其中R1为具有5至15个碳原子的烷基基团,R2为甲基基团或苯基团。
  • Silinane compounds as cysteine protease inhibitors
    申请人:Link O. John
    公开号:US20070088001A1
    公开(公告)日:2007-04-19
    The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is also directed to pharmaceutical compositions comprising these compounds and processes for preparing them. The present invention is also directed to the use of these inhibitors in combination with a therapy that causes a deleterious immune response in patients receiving the therapy.
    本发明涉及一种抑制半胱氨酸蛋白酶的化合物,特别是抑制B、K、L、F和S型蛋白酶,因此可用于治疗由这些蛋白酶介导的疾病。本发明还涉及包含这些化合物的制药组合物和其制备方法。本发明还涉及在治疗引起患者免疫反应不良的疗法中与这些抑制剂的联合使用。
  • Acyltryptophanols
    申请人:Wortmann Lars
    公开号:US20070060573A1
    公开(公告)日:2007-03-15
    The present patent application relates to acyltryptophanols of the general formula I, in which Q, X, Y, W, R1, R2, R3, R4, R5, R8 have the meanings stated in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.
    本专利申请涉及一般式I的酰基色氨酸醇,其中Q、X、Y、W、R1、R2、R3、R4、R5、R8具有说明书中所述的含义。本发明的化合物是有效的FSH拮抗剂,例如可用于男性或女性的生育控制,或用于骨质疏松症的预防和/或治疗。
  • PROCESS FOR PRODUCING IMIDAZOPYRIDINE DERIVATIVE AND INTERMEDIATE
    申请人:Eisai Co., Ltd.
    公开号:EP0627433A1
    公开(公告)日:1994-12-07
    The invention provides an industrially excellent process for producing a 2-alkyl-3-(biphenyl-4-yl)-methyl-3H-imidazo[4,5-b]pyridine derivative represented by general formula (II), serving as a precursor of the angiotensin II receptor antagonist useful as an antihypertensive, a biphenyl derivative serving as a precursor of the substituent of the imidazopyridine derivative, a process for producing the biphenyl derivative, and an intermediate useful for producing the biphenyl derivative. The imidazopyridine derivative (II) can be produced in a high yield according to the process of the invention by subjecting a 2-amino-5-halogeno-3-nitropyridine derivative to amidation, N-alkylation and reductive cyclization. This process is industrially excellent, because the halogen atom introduced into the 5-position as a protective group in the nitration step can be eliminated simultaneously in the subsequent step. The above biphenyl derivative is excellent in reactivity and product purity, thus being an intermediate suitable for industrial production.
    本发明提供了一种生产通式(II)代表的 2-烷基-3-(联苯-4-基)-甲基-3H-咪唑并[4,5-b]吡啶衍生物的工业化优良工艺,该衍生物可作为血管紧张素 II 受体拮抗剂的前体,用于抗高血压、作为咪唑并吡啶衍生物取代基前体的联苯衍生物,生产联苯衍生物的工艺,以及生产联苯衍生物的中间体。根据本发明的工艺,通过对 2-氨基-5-卤代-3-硝基吡啶衍生物进行酰胺化、N-烷基化和还原环化,可以高产率生产出咪唑吡啶衍生物 (II)。由于在硝化步骤中作为保护基团引入 5 位的卤素原子可以在后续步骤中同时消除,因此该工艺在工业上非常出色。上述联苯衍生物在反应活性和产品纯度方面都非常出色,因此是一种适合工业化生产的中间体。
  • SILINANE COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS
    申请人:Schering Aktiengesellschaft
    公开号:EP1716158A2
    公开(公告)日:2006-11-02
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