3-(Propyldisulfanyl)propanoic acid | 112401-23-7

• 分子结构分类: 有机化合物 - 有机硫化合物 - 有机二硫化物
• 英文名称: 3-(Propyldisulfanyl)propanoic acid
• CAS: 112401-23-7
• 化学式: C₆H₁₂O₂S₂
• 分子量: 180.3
• InChiKey: AFBLIRCFRVJJQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  87.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Surface modification for improving biocompatibility
  申请人：The Children's Hospital of Philadelphia

  公开号：US20030044408A1

  公开（公告）日：2003-03-06

  A therapeutic delivery system efficiently introduces biologically active molecules to mammalian cells without the use of synthetic polymers or biopolymer coatings. Surface modification of a metal support, such as a medical device, results in a single molecular layer that can fasten various molecules, thereby minimizing any cellular inflammatory response while enhancing biocompatibility.

  一种治疗性输送系统能够高效地将生物活性分子引入哺乳动物细胞，而无需使用合成聚合物或生物聚合物涂层。对金属支撑物进行表面改性，如医疗器械，形成一个单分子层，可固定各种分子，从而最大程度地减少细胞炎症反应，同时增强生物相容性。
• Modified nucleotides
  申请人：Milton John

  公开号：US20090325172A1

  公开（公告）日：2009-12-31

  The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3′-OH blocking group covalently attached thereto, such that the 3′ carbon atom has attached a group of the structure —O-Z wherein Z is any of —C(R′)2-O—R″, —C(R′)2-N(R″)2, —C(R′)2-N(H)R″, —C(R′)2-S—R″ and —C(R′)2-F, wherein each R″ is or is part of a removable protecting group; each R′ is independently a hydrogen atom, an alkyl, substituted alkyl, arylalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclic, acyl, cyano, alkoxy, aryloxy, heteroaryloxy or amido group, or a detectable label attached through a linking group; or (R′)2 represents an alkylidene group of formula ═C(R′″)2 wherein each R′″ may be the same or different and is selected from the group comprising hydrogen and halogen atoms and alkyl groups; and wherein said molecule may be reacted to yield an intermediate in which each R″ is exchanged for H or, where Z is —C(R′)2-F, the F is exchanged for OH, SH or NH2, preferably OH, which intermediate dissociates under aqueous conditions to afford a molecule with a free 3′OH; with the proviso that where Z is —C(R′)2-S—R″, both R′ groups are not H.

  该发明提供了一种经改性的核苷酸或核苷分子，包括嘌呤或嘧啶碱基和一个核糖或去氧核糖糖基团，其中可移除的3'-OH阻断基团共价连接在其上，使得3'碳原子上附有结构式为-O-Z的基团，其中Z是-C（R'）2-O-R"、-C（R'）2-N（R"）2、-C（R'）2-N（H）R"、-C（R'）2-S-R"和-C（R'）2-F中的任意一种，其中每个R"是或是可移除的保护基团的一部分；每个R'独立地是氢原子、烷基、取代烷基、芳基烷基、烯基、炔基、芳基、杂芳基、杂环、酰基、氰基、烷氧基、芳氧基、杂芳氧基或酰胺基，或通过连接基团连接的可检测标记；或（R'）2表示公式═C（R' "）2的烷基亚甲基，其中每个R' "可以相同或不同，选自氢原子和卤素原子和烷基；其中所述分子可以反应生成一种中间体，在该中间体中，每个R"被交换为H或者当Z为-C（R'）2-F时，F被交换为OH、SH或NH2，优选为OH，在水条件下，该中间体解离以得到具有自由3'OH的分子；但其中当Z为-C（R'）2-S-R"时，两个R'基团不是H。
• MODIFIED NUCLEOTIDES
  申请人：MILTON John

  公开号：US20120095201A1

  公开（公告）日：2012-04-19

  Provided herein is a method for replacing the allyl group in a compound of formula R—O-allyl, R 2 N(allyl), RNH(allyl), RN(allyl) 2 or R—S-allyl with a hydrogen, using a transition metal and one or more phosphine ligands.

  本文提供了一种使用过渡金属和一个或多个膦配体将化合物中公式为R-O-烯丙基、R2N(烯丙基)、RNH(烯丙基)、RN(烯丙基)2或R-S-烯丙基的烯丙基基团替换为氢的方法。
• [EN] PROCESS OF MAKING N,N'-DIACETYL-L-CYSTINE<br/>[FR] PROCÉDÉ DE PRODUCTION DE N,N'-DIACÉTYL-L-CYSTINE
  申请人：UNILEVER IP HOLDINGS B V

  公开号：WO2021219375A1

  公开（公告）日：2021-11-04

  An effective process of making Ν,Ν'-diacetyl-L-Cystine ("NDAC"), which process is fast, green, does not require labor-intensive isolation or purification of the product, by yielding products in desired ratio, and has improved yield and purity. The process comprising the steps of Forming a reaction mixture, starting with a cystine derivative di-tert- butyl-L-cystine as the dihydrochloride form; Acetylating said di-tert-butyl-L-cystine to obtain Ν,Ν'-diacetyl-di-tert- butyl-L-cystine; followed by Removing said tert- butyl groups from said Ν,Ν'-diacetyl-di-tert-butyl- L-cystine to obtain Ν,Ν'-diacetyl-L-cystine product; and Isolating said Ν,Ν'-diacetyl-L-Cystine product from said reaction mixture; wherein said acetylating agent is acetic anhydride.

  一种制备Ν,Ν'-二乙酰-L-半胱氨酸（“NDAC”）的有效过程，该过程快速、环保，不需要耗费大量劳动力进行产品的分离或纯化，通过产生所需比例的产物，且产量和纯度得到改善。该过程包括以下步骤：形成反应混合物，以二叔丁基-L-半胱氨酸衍生物二叔丁基-L-半胱氨酸二盐酸盐形式为起始物；乙酰化该二叔丁基-L-半胱氨酸以获得Ν,Ν'-二乙酰-二叔丁基-L-半胱氨酸；随后从Ν,Ν'-二乙酰-二叔丁基-L-半胱氨酸中去除叔丁基基团以获得Ν,Ν'-二乙酰-L-半胱氨酸产物；并从所述反应混合物中分离所述Ν,Ν'-二乙酰-L-半胱氨酸产物；其中所述乙酰化试剂为乙酸酐。
• IMPROVEMENTS IN OR RELATING TO POLYNUCLEOTIDE ARRAYS
  申请人：Illumina Cambridge Limited

  公开号：EP1692152B1

  公开（公告）日：2010-09-01