2-[diisopropyl(1-naphthyl)silyl]pyrimidine | 1369625-73-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-[diisopropyl(1-naphthyl)silyl]pyrimidine
• CAS: 1369625-73-9
• 化学式: C₂₀H₂₄N₂Si
• 分子量: 320.509
• InChiKey: JGWAELBHXFDWLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.01
• 重原子数：
  23.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  25.78
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  2-[diisopropyl(1-naphthyl)silyl]pyrimidine 、 二(叔丁基羰基氧基)碘苯 在 lithium acetate 、 palladium diacetate 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 20.0h， 以87%的产率得到1-[diisopropyl(pyrimidin-2-yl)silyl]-2-naphthyl pivalate
  参考文献：
  名称：

  Double-Fold C–H Oxygenation of Arenes Using PyrDipSi: a General and Efficient Traceless/Modifiable Silicon-Tethered Directing Group

  摘要：

  The efficient Pd-catalyzed double-fold C-H oxygenation of arenes into resorcinols using the newly developed 2-pyrimidyldiisopropylsilyl (PyrDipSi) directing group is described. Its use allows for the sequential introduction of OAc and OPiv groups in a one-pot manner to produce orthogonally protected resorcinol derivatives. The PyrDipSi group is superior to the previously developed 2-pyridyldiisopropylsilyl (PyDipSi) group, as it is efficient for monooxygenation of ortho-substituted arenes. Notably, the PyrDipSi group can be easily installed into arene molecules and can be easily removed or modified after the oxygenation reaction.

  DOI：

  10.1021/ja3010545
• 作为产物：
  描述：

  1-碘萘 、 2-(diisopropylsilyl)pyrimidine 在 dirhodium tetraacetate 、 potassium phosphate 作用下， 以 1,4-二氧六环 为溶剂， 反应 20.0h， 以60%的产率得到2-[diisopropyl(1-naphthyl)silyl]pyrimidine
  参考文献：
  名称：

  Double-Fold C–H Oxygenation of Arenes Using PyrDipSi: a General and Efficient Traceless/Modifiable Silicon-Tethered Directing Group

  摘要：

  The efficient Pd-catalyzed double-fold C-H oxygenation of arenes into resorcinols using the newly developed 2-pyrimidyldiisopropylsilyl (PyrDipSi) directing group is described. Its use allows for the sequential introduction of OAc and OPiv groups in a one-pot manner to produce orthogonally protected resorcinol derivatives. The PyrDipSi group is superior to the previously developed 2-pyridyldiisopropylsilyl (PyDipSi) group, as it is efficient for monooxygenation of ortho-substituted arenes. Notably, the PyrDipSi group can be easily installed into arene molecules and can be easily removed or modified after the oxygenation reaction.

  DOI：

  10.1021/ja3010545