1,1-Dimethylethyl N-(5-amino-2-pyrazinyl)-N-methylcarbamate | 920313-93-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1,1-Dimethylethyl N-(5-amino-2-pyrazinyl)-N-methylcarbamate
• 英文别名: tert-butyl N-(5-aminopyrazin-2-yl)-N-methylcarbamate
• CAS: 920313-93-5
• 化学式: C₁₀H₁₆N₄O₂
• 分子量: 224.26
• InChiKey: HQPGZWWNIAKTLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  81.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Oxime Derivative and Preparations Thereof
  申请人：Sugawara Kazutoshi

  公开号：US20080132479A1

  公开（公告）日：2008-06-05

  The problem of the present invention is to provide a useful compound as a glucokinase activating agent, which is the oxime derivative of the formula [I]: wherein Ring A is aryl or heteroaryl; Q is cycloalkyl, heterocycle, alkyl or alkenyl; Ring T is heteroaryl or heterocycle; R 1 and R 2 are independently hydrogen atom, halogen atom, cycloalkylsulfonyl or the like; R 3 and R 4 are independently hydrogen atom, hydroxy, oxo, halogen atom or the like; R 5 is hydrogen atom, halogen atom, cyano, nitro, tetrazolyl or the like; or a pharmaceutically acceptable salt thereof.

  本发明的问题是提供一种有用的化合物作为葡萄糖激酶活化剂，其为式[I]的肟衍生物：其中，环A是芳基或杂芳基；Q是环烷基，杂环，烷基或烯基；环T是杂芳基或杂环；R1和R2分别是氢原子，卤素原子，环烷基磺酰基或类似物；R3和R4分别是氢原子，羟基，氧代，卤素原子或类似物；R5是氢原子，卤素原子，氰基，硝基，四唑基或类似物；或其药学上可接受的盐。
• OXIME DERIVATIVE AND PREPARATIONS THEREOF
  申请人：Sugawara Kazutoshi

  公开号：US20090291936A1

  公开（公告）日：2009-11-26

  The problem of the present invention is to provide a useful compound as a glucokinase activating agent, which is the oxime derivative of the formula [I]: wherein Ring A is aryl or heteroaryl; Q is cycloalkyl, heterocycle, alkyl or alkenyl; Ring T is heteroaryl or heterocycle; R 1 and R 2 are independently hydrogen atom, halogen atom, cycloalkylsulfonyl or the like; R 3 and R 4 are independently hydrogen atom, hydroxy, oxo, halogen atom or the like; R 5 is hydrogen atom, halogen atom, cyano, nitro, tetrazolyl or the like; or a pharmaceutically acceptable salt thereof.

  本发明的问题是提供一种有用的化合物作为葡萄糖激酶活化剂，该化合物是公式[I]的肟衍生物： 其中，环A是芳基或杂环芳基；Q是环烷基、杂环、烷基或烯基；环T是杂环芳基或杂环；R1和R2分别是氢原子、卤素原子、环烷基磺酰基或类似物；R3和R4分别是氢原子、羟基、氧代、卤素原子或类似物；R5是氢原子、卤素原子、氰基、硝基、四唑基或类似物；或其药学上可接受的盐。
• US7514439B2
  申请人：——

  公开号：US7514439B2

  公开（公告）日：2009-04-07
• US8119626B2
  申请人：——

  公开号：US8119626B2

  公开（公告）日：2012-02-21
• [EN] AN OXIME DERIVATIVE AND PREPARATIONS THEREOF<br/>[FR] DERIVE D'OXIME ET SES PREPARATIONS
  申请人：TANABE SEIYAKU CO

  公开号：WO2007007886A1

  公开（公告）日：2007-01-18

  [EN] The problem of the present invention is to provide a useful compound as a glucokinase activating agent, which is the oxime derivative of the formula [I]: wherein Ring A is aryl or heteroaryl; Q is cycloalkyl, heterocycle, alkyl or alkenyl; Ring T is heteroaryl or heterocycle; R¹ and R² are independently hydrogen atom, halogen atom, cycloalkylsulfonyl or the like; R³ and R⁴ are independently hydrogen atom, hydroxy, oxo, halogen atom or the like; R⁵ is hydrogen atom, halogen atom, cyano, nitro, tetrazolyl or the like; or a pharmaceutically acceptable salt thereof.
  [FR] L'invention concerne un composé utilisé comme agent d'activation de la glucokinase, qui est un dérivé d'oxime représenté par la formule [I]. Dans cette formule, le noyau A représente aryle ou hétéroaryle; Q représente cycloalkyle, hétérocycle, alkyle ou alcényle; le noyau T représente hétéroaryle ou hétérocycle; R¹ et R² représentent indépendamment un atome d'hydrogène, un atome d'halogène, cycloalkylsulfonyle ou analogue; R³ et R⁴ représentent indépendamment un atome d'hydrogène, hydroxy, oxo, un atome d'halogène ou analogue; R⁵ représente un atome d'hydrogène, un atome d'halogène, cyano, nitro, tétrazolyle ou analogue. L'invention concerne également un sel de ce composé pharmaceutiquement acceptable.