| 1337924-69-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 1337924-69-2
• 化学式: C₁₆H₂₁NO₃
• 分子量: 275.348
• InChiKey: GPYLLHZJCQXCBJ-AWEZNQCLSA-N

反应信息

• 作为反应物：
  描述：

  在 alumina-supported P₂S₅ 作用下， 以 四氢呋喃 为溶剂， 反应 0.08h， 以77%的产率得到[(2S)-1-(2-phenylethanethioyl)pyrrolidin-2-yl]methyl propanoate
  参考文献：
  名称：

  Thionation of amides using a solid-supported P2S5 reagent under microwave irradiation

  摘要：

  In this Letter, we describe an improved method for the thionation of amides. Using a solid-supported P2S5 reagent, heating under microwave irradiation furnished thioamides in good to excellent yields, with a significantly reduced reaction time compared with that achieved under conventional heating. Furthermore, a change of solvent from that described in the literature enabled a simplified work-up and purification of the products. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.07.104