2-isopropyl-6-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-1,2,3,4-tetrahydro-isoquinoline | 1350411-06-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 2-isopropyl-6-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-1,2,3,4-tetrahydro-isoquinoline
• 英文别名: 6-[(3S)-3-[(2S)-2-methylpyrrolidin-1-yl]pyrrolidin-1-yl]-2-propan-2-yl-3,4-dihydro-1H-isoquinoline
• CAS: 1350411-06-1
• 化学式: C₂₁H₃₃N₃
• 分子量: 327.513
• InChiKey: JABWJOPTZAQAHE-UWJYYQICSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  9.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• SUBSTITUTED N-ALKYL AND N-ACYL TETRAHYDRO-ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF
  申请人：SANOFI

  公开号：US20130065919A1

  公开（公告）日：2013-03-14

  The present disclosure relates to a series of substituted N-alkyl and N-acyl tetrahydro-isoquinoline derivatives of formula (I). wherein R, R 1 , R 2 , X, m, n and p are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, this disclosure also relates to methods of preparation of substituted N-alkyl and N-acyl tetrahydro-isoquinoline derivatives of formula (I) and intermediates therefor.

  本公开涉及一系列式(I)的取代N-烷基和N-酰基四氢异喹啉衍生物，其中R、R1、R2、X、m、n和p如本文所述。更具体地说，本发明的化合物是H3受体调节剂，因此在治疗和/或预防包括与中枢神经系统相关的多种受H3受体调节的疾病中，特别有用作为药物制剂。此外，本公开还涉及制备式(I)的取代N-烷基和N-酰基四氢异喹啉衍生物及其中间体的方法。
• US8871788B2
  申请人：——

  公开号：US8871788B2

  公开（公告）日：2014-10-28