5,6-dihydroxy-N-(2-methylcyclohexyl)-2-(pyridin-2-yl)pyrimidine-4-carboxamide | 1407170-04-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5,6-dihydroxy-N-(2-methylcyclohexyl)-2-(pyridin-2-yl)pyrimidine-4-carboxamide
• 英文别名: 5,6-dihydroxy-N-(2-methylcyclohexyl)-2-(2-pyridyl)pyrimidine-4-carboxamide；5-hydroxy-N-(2-methylcyclohexyl)-6-oxo-2-pyridin-2-yl-1H-pyrimidine-4-carboxamide
• CAS: 1407170-04-0
• 化学式: C₁₇H₂₀N₄O₃
• 分子量: 328.371
• InChiKey: XGDUHFVFDQKGOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] PYRIMIDINONE COMPOUNDS AND METHODS FOR PREVENTING AND TREATING INFLUENZA<br/>[FR] COMPOSÉS DE PYRIMIDINONE ET MÉTHODES DE PRÉVENTION ET DE TRAITEMENT DE LA GRIPPE
  申请人：ST JUDE CHILDRENS RES HOSPITAL

  公开号：WO2012151567A1

  公开（公告）日：2012-11-08

  In one aspect, the invention relates to novel, broad-spectrum anti-viral, pyrimidinone compounds, methods of use, compositions and kits useful in treating and/or preventing influenza. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  在一个方面，该发明涉及新颖的、广谱抗病毒的嘧啶酮化合物，以及用于治疗和/或预防流感的方法、组合物和工具包。本摘要旨在作为在特定领域进行搜索的扫描工具，并不意味着对本发明的限制。
• HIV-1 NUCLEOCAPSID INHIBITORS
  申请人：Università degli Studi di Siena

  公开号：EP3290412A1

  公开（公告）日：2018-03-07

  The present invention discloses novel anti-HIV agents targeting the HIV Nucleocapsid protein (NC), which is one of the most conserved sequences within HIV strains and is highly required for HIV replication. The compounds of the invention are particularly useful to overcome antiretroviral drug-resistance in HIV-1 infected individuals.

  本发明揭示了针对HIV核壳蛋白（NC）的新型抗HIV药物，该蛋白是HIV菌株中最保守的序列之一，对HIV复制非常重要。本发明的化合物特别适用于克服HIV-1感染个体中的抗逆转录病毒药物耐药性。
• PYRIMIDINONE COMPOUNDS AND METHODS FOR PREVENTING AND TREATING INFLUENZA
  申请人：Webb Thomas R.

  公开号：US20140079666A1

  公开（公告）日：2014-03-20

  In one aspect, the invention relates to novel, broad-spectrum anti-viral, pyrimidinone compounds, methods of use, compositions and kits useful in treating and/or preventing influenza. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• US9328075B2
  申请人：——

  公开号：US9328075B2

  公开（公告）日：2016-05-03