3-[3-(3,3-Dimethylbut-1-ynyl)-4-hydroxyphenyl]propanoic acid | 1371597-99-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 3-[3-(3,3-Dimethylbut-1-ynyl)-4-hydroxyphenyl]propanoic acid
• CAS: 1371597-99-7
• 化学式: C₁₅H₁₈O₃
• 分子量: 246.306
• InChiKey: YLJRLIUTCITPIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-[3-(3,3-Dimethylbut-1-ynyl)-4-hydroxyphenyl]propanoic acid 在 bis-triphenylphosphine-palladium(II) chloride 、 亚碘酰苯 作用下， 以 2,2,2-三氟乙醇 、 1,2-二氯乙烷 为溶剂， 反应 0.03h， 生成 8-tert-butyl-1-p-tolyl-3,4-dihydrofuro[2,3-h]quinolin-2(1H)-one
  参考文献：
  名称：

  Application of Dearomatization Strategy on the Synthesis of Furoquinolinone and Angelicin Derivatives

  摘要：

  The oxidative dearomatization of 3-(3-alkynyl-4-hydroxyphenyl)propanoic acid is combined with a cascade transition-metal catalyzed cyclization/addition/aromatization/lactamization sequence, which provides a novel approach to prepare furoquinolinone and angelicin derivatives in a convergent and efficient manner.

  DOI：

  10.1021/ol300648t

文献信息

• Application of Dearomatization Strategy on the Synthesis of Furoquinolinone and Angelicin Derivatives
  作者：Yang Ye、Li Zhang、Renhua Fan

  DOI：10.1021/ol300648t

  日期：2012.4.20

  The oxidative dearomatization of 3-(3-alkynyl-4-hydroxyphenyl)propanoic acid is combined with a cascade transition-metal catalyzed cyclization/addition/aromatization/lactamization sequence, which provides a novel approach to prepare furoquinolinone and angelicin derivatives in a convergent and efficient manner.