8-methyl-5,6,7,8-tetrahydro-imidazo[1,2-a]pyrimidine | 65092-05-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 8-methyl-5,6,7,8-tetrahydro-imidazo[1,2-a]pyrimidine
• 英文别名: 8-methyl-6,7-dihydro-5H-imidazo[1,2-a]pyrimidine
• CAS: 65092-05-9
• 化学式: C₇H₁₁N₃
• 分子量: 137.184
• InChiKey: DFNYOYSZSWULMY-UHFFFAOYSA-N

物化性质

• 沸点：
  262.1±23.0 °C(Predicted)
• 密度：
  1.20±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  21.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  8-methyl-5,6,7,8-tetrahydro-imidazo[1,2-a]pyrimidine 、 硝酸 、 溶剂黄146 以8%的产率得到
  参考文献：
  名称：

  NAGARAJAN K.; ARYA V. P.; SHENOY S. J.; SHAH R. K.; GOUD A. N.; BHAT G. A+, INDIAN J. CHEM., 1977, B 15, HO 7, 629-634

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(2,2-dimethoxyethyl)-1-methyl-5,6-dihydro-4H-pyrimidin-2-amine;hydroiodide 、 盐酸 、 异丙醇 、 sodium hydroxide 以80%的产率得到
  参考文献：
  名称：

  NAGARAJAN K.; ARYA V. P.; SHENOY S. J.; SHAH R. K.; GOUD A. N.; BHAT G. A+, INDIAN J. CHEM., 1977, B 15, HO 7, 629-634

  摘要：

  DOI：

文献信息

• [EN] METALLO-BETA-LACTAMASE INHIBITORS AND METHODS OF USE THEREOF<br/>[FR] INHIBITEURS DE LA MÉTALLO-BÊTA-LACTAMASE ET LEURS MÉTHODES D'UTILISATION
  申请人：MERCK SHARP & DOHME

  公开号：WO2019135920A1

  公开（公告）日：2019-07-11

  The present invention relates to metallo-β-lactamase inhibitor compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein RA, R1, and Z are as defined herein. The present invention also relates to compositions which comprise a metallo-β-lactamase inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more β-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for overcoming antibiotic resistance.

  本发明涉及式I的金属β-内酰胺酶抑制剂化合物及其药用盐，其中RA、R1和Z如本文所定义。本发明还涉及包含本发明的金属β-内酰胺酶抑制剂化合物或其药用盐的组合物，以及药用载体，可选择与β-内酰胺类抗生素和/或β-内酰胺酶抑制剂结合使用。本发明还涉及治疗细菌感染的方法，包括向患者施用本发明的化合物的治疗有效量，与一个或多个β-内酰胺类抗生素的治疗有效量组合使用，可选择与一个或多个β-内酰胺酶抑制剂化合物组合使用。本发明的化合物在本文所述方法中用于克服抗生素耐药性。
• Aminocyclohexanes as Dipeptidyl Peptidase-Iv Inhibitors for the Treatment or Prevention of Diabetes
  申请人：Biftu Tesfaye

  公开号：US20070254865A1

  公开（公告）日：2007-11-01

  The present invention is directed to novel substituted aminocyclohexanes which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

  本发明涉及新型的取代氨基环己烷，其为二肽基肽酶-IV酶（“DPP-IV抑制剂”）的抑制剂，并且对于二肽基肽酶-IV酶参与的疾病，例如糖尿病和特别是2型糖尿病的治疗或预防有用。该发明还涉及包含这些化合物的制药组合物以及在预防或治疗二肽基肽酶-IV酶参与的这些疾病中使用这些化合物和组合物。
• US7482336B2
  申请人：——

  公开号：US7482336B2

  公开（公告）日：2009-01-27