N-benzyl-N-(1-benzylpyrrolidine-3-yl)-4-isopropylbenzenesulfonamide | 1285543-67-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzyl-N-(1-benzylpyrrolidine-3-yl)-4-isopropylbenzenesulfonamide
• 英文别名: N-benzyl-N-(1-benzylpyrrolidin-3-yl)-4-propan-2-ylbenzenesulfonamide
• CAS: 1285543-67-0
• 化学式: C₂₇H₃₂N₂O₂S
• 分子量: 448.629
• InChiKey: OZEYUNDLLSQIBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  49
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] SULFONAMIDE DERIVATIVES AS SEROTONIN RECEPTOR ANTAGONIST AND SEROTONIN REUPTAKE INHIBITOR<br/>[FR] DÉRIVÉS DE SULFONAMIDE EN TANT QU'ANTAGONISTE DES RÉCEPTEURS DE LA SÉROTONINE ET INHIBITEUR DE LA RECAPTURE DE LA SÉROTONINE
  申请人：KOREA INST SCI & TECH

  公开号：WO2011043519A2

  公开（公告）日：2011-04-14

  The present invention relates to sulfonamide derivatives as a serotonin receptor antagonist and serotonin reuptake inhibitor and a pharmaceutically acceptable salt thereof. The sulfonamide derivatives have serotonin 5-HT2A and 5-HT2C receptor antagonizing and serotonin reuptake inhibiting functions, and thus may be efficiently applied to a CNS-related disease such as depression, obesity, psychosis, schizophrenia, suicidal tendency, anxiety, obsessional neurosis, migraine, appetite disorders, sleep disorders, stroke, and withdrawal symptoms caused by drug abuse.