ethyl (2S)-2-[[1-[(2S,3R,4R,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]ethoxy-(4-chlorophenoxy)phosphoryl]amino]propanoate | 1417563-38-2

• 分子结构分类: 有机化合物
• 英文名称: ethyl (2S)-2-[[1-[(2S,3R,4R,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]ethoxy-(4-chlorophenoxy)phosphoryl]amino]propanoate
• CAS: 1417563-38-2
• 化学式: C₂₄H₃₀ClFN₅O₇P
• 分子量: 585.957
• InChiKey: VDOJVGXDLXTWSQ-XMCCYAIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  39
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  160
• 氢给体数：
  3
• 氢受体数：
  12

文献信息

• 5'-SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
  申请人：Verma Vishal A.

  公开号：US20140235567A1

  公开（公告）日：2014-08-21

  The present invention relates to 5′-Substituted Nucleoside Derivatives of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein B, X, Y, Z, R 1 , R 2 , R 3 and R 3′ are as defined herein. The present invention also relates to compositions comprising at least one 5′-Substituted Nucleoside Derivative, and methods of using the 5′-Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
• US9416154B2
  申请人：——

  公开号：US9416154B2

  公开（公告）日：2016-08-16