1-methyl-3-difluoromethyl-1H-pyrazole-4-carboxylic acid (2',4',5'-trifluorobiphenyl-2-yl)-amide | 907204-32-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-methyl-3-difluoromethyl-1H-pyrazole-4-carboxylic acid (2',4',5'-trifluorobiphenyl-2-yl)-amide
• 英文别名: N-(2',4',5'-trifluorobiphenyl-2-yl)-3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxamide；N-(2',4',5'-trifluorobiphenyl-2-yl)-1-methyl-3-difluoromethyl-1H-pyrazole-4-carboxamide；N-(2',4',5'-trifluorobiphenyl-2-yl)-3-difluoromethyl-1-methylpyrazol-4-ylcarboxamide；3-(difluoromethyl)-1-methyl-N-(2',4',5'-trifluorobiphenyl-2-yl)-1H-pyrazole-4-carboxamide；3-(difluoromethyl)-1-methyl-N-[2-(2,4,5-trifluorophenyl)phenyl]pyrazole-4-carboxamide
• CAS: 907204-32-4
• 化学式: C₁₈H₁₂F₅N₃O
• 分子量: 381.305
• InChiKey: OXBRSAWHLLAWFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  46.9
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid (3',4',5'-trifluorobiphenyl-2-yl)-amide 、 氟苯吡菌胺 、 1-methyl-3-difluoromethyl-1H-pyrazole-4-carboxylic acid (2',4',5'-trifluorobiphenyl-2-yl)-amide 、 N-(3',4',5'-trifluorobiphenyl-2-yl)-3-chlorofluoromethyl-1-methyl-1H-pyrazole-4-carboxamide 、 N-[2-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamide 、 3-(difluoromethyl)-1-methyl-N-[2-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]-1H-pyrazole-4-carboxamide 、 N-[2-(2-chloro-1,1,2-trifluoroethoxy)phenyl]-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamide 、 n-[2-(2-Chlor-1,1,2-trifluoroethoxy)phenyl]-3-difluoromethyl-1-methyl-1h-pyrazole-4-carboxamide 、 3-(difluoromethyl)-1-methyl-N-[2-(1,1,2,2-tetrafluoroethoxy)phenyl]-1H-pyrazol-4-carboxamide 、 N-[2-(1,1,2,2-tetrafluoroethoxy)phenyl]-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamide 、 N-(4'-(trifluoromethylthio)biphenyl-2-yl)-3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxamide 、 N-(4'-(trifluoromethylthio)biphenyl-2-yl)-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxamide 生成 1-methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid (4'-chloro-2'-fluoro-5'-methylbiphenyl-2-yl)-amide
  参考文献：
  名称：

  Fungicidal Mixtures

  摘要：

  本发明涉及混合物，包括以下活性成分：1）式（I）的杀真菌化合物，其中：R1是烷基；烷氧基烷基；卤代烷基；芳基烷基；芳基；或杂环芳基；R2是烷基；烷氧基烷基；卤代烷基；芳基烷基；芳基；杂环芳基；5-嘧啶基；或2-或5-噻唑基；R3是H；烷基；烷氧基烷基；卤代烷基；芳基烷基；芳氧基烷基；芳硫基烷基；芳基；杂环芳基；或烷基硅基；R4是H；酰基；卤代酰基；烷氧羰基；芳基氧羰基；烷基氨基羰基；或二烷基氨基羰基；或其盐；以及2）从咪唑类，斯特罗比林，卡波酰胺，杂环化合物，氨基甲酸酯和其他活性化合物中选择的杀真菌化合物II，以协同有效量混合。

  公开号：

  US20100179059A1

文献信息

• Method for preparing 1,3,4-substituted pyrazol compounds
  申请人：Wolf Bernd

  公开号：US20110172436A1

  公开（公告）日：2011-07-14

  The invention provides an Ethernet bridge or router comprising a network fabric adapted to provide interconnectivity to a plurality of Ethernet ports, each of the Ethernet ports being adapted to receive and/or transmit Ethernet frames, and wherein the Ethernet bridge or router further comprises an encapsulator connected to receive Ethernet Protocol Data Units from the Ethernet ports, wherein the encapsulator is operable to generate a Fabric Protocol Data Unit from a received Ethernet Protocol Data Unit, the Fabric Protocol Data Unit comprising a header portion, and a payload portion which comprises the Ethernet Protocol Data Unit concerned, and wherein the encapsulator is operable to transform Ethernet destination address information from the Ethernet Protocol Data Unit into a routing definition for the network fabric, and to include this routing definition in the header portion of the Fabric Protocol Data Unit. Also provided is a method of data delivery across a network.

  该发明提供了一种以太网桥或路由器，包括一个网络结构，适用于为多个以太网端口提供互连性，每个以太网端口适用于接收和/或传输以太网帧，以及该以太网桥或路由器进一步包括一个封装器，连接到以太网端口以接收以太网协议数据单元，其中该封装器能够从接收到的以太网协议数据单元生成一个面向网络结构的协议数据单元，该面向网络结构的协议数据单元包括一个头部部分和一个负载部分，该负载部分包括所涉及的以太网协议数据单元，该封装器能够将以太网协议数据单元中的目的地址信息转换为网络结构的路由定义，并将该路由定义包含在面向网络结构的协议数据单元的头部部分中。还提供了一种通过网络进行数据传递的方法。
• Fungicidal Compounds, Method For the Production Thereof, And Use Thereof To Combat Damaging Fungi, And Agents Comprising The Same
  申请人：Rheinheimer Joachim

  公开号：US20100304966A1

  公开（公告）日：2010-12-02

  Compounds of the formula I in which the substituents have the meaning given in the description, processes for preparing these compounds, compositions comprising them and their use for controlling harmful fungi.

  该式化合物I的取代基在描述中给出其含义，制备这些化合物的方法，包含它们的组合物以及它们用于控制有害真菌的用途。
• Method For Manufacturing Aryl Carboxamides
  申请人：Reichert Wolfgang

  公开号：US20110054183A1

  公开（公告）日：2011-03-03

  A process for preparing arylcarboxamides of the formula (I) where Ar =a mono- to trisubstituted phenyl, pyridyl or pyrazolyl ring, where the substituents are selected from halogen, C i -C 4 -alkyl and C 1 -C 4 -haloalkyl; M =thienyl or phenyl, which may bear a halogen substituent; Q =direct bond, cyclopropylene, fused bicycio[2.2.1]heptane or bicyclo[2.2.1]heptene ring; R 1 =hydrogen, halogen, C 1 -C 6 -alkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -haloalkoxy, mono- to trisubstituted phenyl, where the substituents are selected from halogen and trifluoromethylthio, or cyclopropyl; by reacting an acid chloride of the formula (II) with an arylamine (III) in a suitable nonaqueous solvent, wherein, in the absence of an auxiliary base, a) the acid chloride (II) is initially charged, b) a pressure of from 0 to 700 mbar is established, c) the arylamine (III) is metered in in an approximately stoichiometric amount and d) the product of value is isolated.

  一种制备式(I)的芳基羧酰胺的方法，其中Ar = 单取代至三取代苯基、吡啶基或吡唑基环，取代基选自卤素、Ci-C4-烷基和C1-C4-卤代烷基；M = 噻吩基或苯基，可以带有卤素取代基；Q = 直链键、环丙烯基、融合的双环[2.2.1]庚烷或双环[2.2.1]庚烯环；R1 = 氢、卤素、C1-C6-烷基、C1-C4-烷氧基、C1-C4-卤代烷氧基、单取代至三取代苯基，其中取代基选自卤素和三氟甲硫基，或环丙基；通过在适当的非水溶剂中将式(II)的酸氯与芳香胺(III)反应，其中，在没有辅助碱的情况下，a) 首先加入酸氯(II)，b) 建立0至700毫巴的压力，c) 以近似化学计量的量滴定芳香胺(III)，d) 分离所得产物的价值。
• [EN] PYRIDYLMETHYL-SULFONAMIDE COMPOUNDS<br/>[FR] COMPOSÉS PYRIDYLMÉTHYLE SULFONAMIDE
  申请人：BASF SE

  公开号：WO2009071448A1

  公开（公告）日：2009-06-11

  The present invention relates to novel pyridylmethyl-sulfonamide compounds of formula (I) where: n is 0 to 4; m is 0 to 4; R1 is halogen, CN, NO2, OH, SH, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, etc.; and/or two radicals R1 together form a fused ring; R2 is H, C1-C4-alkyl, C1-C4-haloalkyl, C2-C4-alkenyl, C2-C4-alkynyl, C3-C8-cycloalkyl, C1-C4-alkyl-C3-C8-cycloalkyl or benzyl; R3 is halogen, CN, NO2, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy or C1-C4-haloalkoxy; Y is -O-, C1-C4-alkane- diyl, -O-CH2-, -CH2-O-, -C(NOR')-, -S-, -S(=0)-, -Sf=O)2- or -N(R')-; and the N-oxides, and salts thereof and their use for combating phytopathogenic harmful fungi, and also to compositions and seed comprising at least one such compound.

  本发明涉及一种新型吡啶基甲基磺酰胺化合物，其化学式为（I），其中：n为0至4；m为0至4；R1为卤素、CN、NO2、OH、SH、C1-C4-烷基、C1-C4-卤代烷基、C1-C4-烷氧基、C1-C4-卤代烷氧基等；和/或两个基团R1共同形成融合环；R2为H、C1-C4-烷基、C1-C4-卤代烷基、C2-C4-烯基、C2-C4-炔基、C3-C8-环烷基、C1-C4-烷基-C3-C8-环烷基或苄基；R3为卤素、CN、NO2、C1-C4-烷基、C1-C4-卤代烷基、C1-C4-烷氧基或C1-C4-卤代烷氧基；Y为-O-、C1-C4-烷二基、-O-CH2-、-CH2-O-、-C(NOR')-、-S-、-S(=0)-、-S(=O)2-或-N(R')-；以及其N-氧化物、盐及其用途，用于对抗植物病原真菌，以及包含至少一种这种化合物的组合物和种子。
• Method for the Production of Halogen-Substituted 2-(aminomethylidene)-3-oxobutyric Acid Esters
  申请人：Zierke Thomas

  公开号：US20110040096A1

  公开（公告）日：2011-02-17

  The present invention relates to a process for preparing 2-(aminomethylidene)-4,4-dihalo-3-oxobutyric esters of the formula (I), wherein R 1 , R 2 , R 3 are C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 2 -C 6 -alkenyl, C 3 -C 10 -cycloalkyl or benzyl, and/or R 2 together with R 3 and the nitrogen atom to which the two radicals are attached are a heterocyclic radical, in which a corresponding 3-aminoacrylic ester is reacted with a halogen-substituted acetyl fluoride in the presence of at least one alkali or alkaline earth metal fluoride; and the further conversion of halogen-substituted 2-(aminomethylidene)-3-oxobutyric esters of the formula (I) to halomethyl-substituted pyrazol-4-ylcarboxylic acids and their esters.

  本发明涉及一种制备式(I)的2-(氨甲基亚胺)-4,4-二卤代-3-氧代丁酸酯的方法，其中R1、R2、R3为C1-C6烷基、C1-C6卤代烷基、C2-C6烯基、C3-C10环烷基或苄基，和/或R2与R3以及它们所连接的氮原子是杂环基，其中相应的3-氨基丙烯酸酯在至少一种碱金属或碱土金属氟化物的存在下与卤代乙酰氟反应；以及将卤代2-(氨甲基亚胺)-3-氧代丁酸酯转化为卤代甲基取代的吡唑-4-基羧酸及其酯。