1-((3-Amino-6-chloropyrazin-2-yl)methyl)-3-phenylthiourea | 1173997-58-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-((3-Amino-6-chloropyrazin-2-yl)methyl)-3-phenylthiourea
• 英文别名: 1-[(3-amino-6-chloropyrazin-2-yl)methyl]-3-phenylthiourea
• CAS: 1173997-58-4
• 化学式: C₁₂H₁₂ClN₅S
• 分子量: 293.78
• InChiKey: VVKMRLPJXUGJLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  108
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-((3-Amino-6-chloropyrazin-2-yl)methyl)-3-phenylthiourea 在 氨 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 90.0h， 生成 2-[(3-Amino-6-chloropyrazin-2-yl)methyl]-1-phenylguanidine 、
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of aminopyrazine derivatives as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

  摘要：

  Several series of novel non-thiourea-containing aminopyrazine derivatives were designed based on the MK-2 inhibitors 1-(2-aminopyrazin-3-yl)methyl-2-thioureas. These compounds were synthesized and evaluated for their inhibitory activity against MK-2 enzyme in vitro. Compounds with low micromolar to sub-micromolar IC50 values were identified, and several compounds were also found to be active in suppressing the lipopolysaccharide (LPS)-stimulated TNF alpha production in THP-1 cells with minimum shift compared to their enzyme activity. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.09.016