diethyl ((4-cyanophenyl)(phenylamino)methyl)phosphonate | 1254190-53-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diethyl ((4-cyanophenyl)(phenylamino)methyl)phosphonate
• CAS: 1254190-53-8
• 化学式: C₁₈H₂₁N₂O₃P
• 分子量: 344.35
• InChiKey: KYVURMCWTZCOBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.94
• 重原子数：
  24.0
• 可旋转键数：
  8.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  71.35
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  N-(p-cyanobenzylidene)aniline 、 亚磷酸二乙酯 在 二氯二氧化钼 作用下， 反应 0.08h， 以89%的产率得到diethyl ((4-cyanophenyl)(phenylamino)methyl)phosphonate
  参考文献：
  名称：

  MoO2Cl2 as a novel catalyst for the synthesis of α-aminophosphonates

  摘要：

  This work reports the use of MoO2Cl2 as a novel catalyst for the synthesis of alpha-aminophosphonates. The system HP(O)(OEt)(2)/MoO2Cl2 (5 mol%) was applied in the synthesis of several alpha-aminophosphonates in excellent yields under solvent-free conditions. (c) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.catcom.2010.10.005

文献信息

• Magnetic ZnO@CuO@Iron ore nanocomposites as a green and highly efficient heterogeneous nanocatalyst for solventless synthesis of α-aminophosphonates
  作者：S Mohammad Sajadi

  DOI：10.1177/1747519819883883

  日期：2020.1

  A green novel synthesis of ZnO@CuO@Iron ore nanocomposites as a novel and magnetic heterogeneous nanocatalyst is used for the one-pot synthesis of α-aminophosphonates under solventless conditions. This study benefits from the magnetic iron ore acting as a multi-mineral Lewis acid system, the green properties and the large surface area due to its nanostructure. Moreover, scanning electron microscope

  绿色新型合成 ZnO@CuO@铁矿石纳米复合材料作为一种新型磁性多相纳米催化剂，用于在无溶剂条件下一锅法合成 α-氨基膦酸酯。这项研究受益于磁性铁矿石作为多矿物路易斯酸系统，由于其纳米结构而具有绿色特性和大表面积。此外，扫描电子显微镜分析证实该纳米催化剂具有优异的产率和良好的可回收性；即使在模型反应的第 10 次循环之后，它仍然保持其潜力，催化活性没有显着损失。
• CeCl3·7H2O-catalyzed one-pot Kabachnik-Fields reaction: A green protocol for three-component synthesis of α-aminophosphonates
  作者：Abbas Ali Jafari、Mahshid Nazarpour、Mohammad Abdollahi-Alibeik

  DOI：10.1002/hc.20635

  日期：——

  CeCl3·7H2O has been utilized as an efficient Lewis acid catalyst for the three-component coupling of aldehydes, aromatic amines, and diethylphosphite to produce α-aminophosphonates under solvent-free conditions. The advantages of this protocol are high yield, mild reaction conditions, less environmental pollution, and simple work-up procedure. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:397–403

  CeCl3·7H2O已被用作一种有效的路易斯酸催化剂，用于醛、芳香胺和亚磷酸二乙酯的三组分偶联，在无溶剂条件下生产α-氨基膦酸酯。该协议的优点是收率高、反应条件温和、环境污染少、后处理程序简单。© 2010 Wiley Periodicals, Inc. 杂原子化学 21:397–403, 2010; 在 wileyonlinelibrary.com 上在线查看这篇文章。DOI 10.1002/hc.20635