2-Azido-3-nitro-benzoesaeure | 10223-53-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Azido-3-nitro-benzoesaeure
• 英文别名: 2-Azido-3-nitrobenzoic acid
• CAS: 10223-53-7
• 化学式: C₇H₄N₄O₄
• 分子量: 208.133
• InChiKey: BICBKHSOCDWNIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  97.5
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-Azido-3-nitro-benzoesaeure 以 甲苯 为溶剂， 反应 1.0h， 生成 4-carboxybenzo[c][1,2,5]oxadiazole 1-oxide
  参考文献：
  名称：

  Synthesis and biological evaluation of novel histone deacetylases inhibitors with nitric oxide releasing activity

  摘要：

  A novel series of histone deacetylases inhibitors (HDACIs) containing benzofuroxan pharmacophore as nitric oxide (NO) donor were designed based on the combination principle and 'multifunctional drugs' theory. As a novel study on embedding NO donor into the structure of HDACIs, all designed hybrid compounds, especially 19d and 24d, displayed remarkable HDACs inhibitory activity and outstanding antiproliferative activity on tumor cells. Besides, they could produce high levels of NO in HCT-116 cells; furthermore, their antiproliferative activity on HCT-116 cells could be diminished by pretreatment with hemoglobin, as the NO scavenger, in a dose-dependent manner. All in all, our designed compounds displayed great inhibitory activities and might offer a prospective avenue to discover novel anti-cancer drugs. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.06.015
• 作为产物：
  描述：

  2-溴-3-硝基苯甲酸 在 ammonium hydroxide 作用下， 以 乙醇 为溶剂， 生成 2-Azido-3-nitro-benzoesaeure
  参考文献：
  名称：

  杂环重排。第五部分。4-芳基偶氮和4-亚硝基苯并呋喃类化合物的重排：苯并三唑和苯并呋喃山环系统的新合成

  摘要：

  4-对-茴香基偶氮-5-硝基苯并呋喃喃自发地重排为2-对-茴香基-4,7-二硝基苯并三唑，其结构已通过核磁共振光谱证实。5-二甲基氨基-4-亚硝基苯并呋喃喃自发重排为4-二甲基氨基-7-硝基苯并呋喃，其结构已通过独立合成证明。报道了一些4-氨基苯并呋喃的衍生物的制备。

  DOI：

  10.1039/j29660001004

文献信息

• [EN] TREATMENT OF INFECTIOUS DISEASE<br/>[FR] TRAITEMENT D'UNE MALADIE INFECTIEUSE
  申请人：UNIV ALBERTA

  公开号：WO2019183729A1

  公开（公告）日：2019-10-03

  The present disclosure relates to 2-(3 -indolyl)indolin-3 -one derivatives of the natural product isatisine A, synthesized from dual catalytic synthesis on metalocarbene-azide cascade chemistry, useful for treating a subject having or suspected of having an infectious disease, wherein said infectious disease is caused by a virus, wherein the virus is from the family flaviviridae or paramyxoviridae.

  本公开涉及从自然产物异黄酮A的2-(3-吲哚基)吲哚烷-3-酮衍生物中合成的双催化合成金属卡宾-叠氮化合物级联化学，用于治疗患有或疑似患有传染病的受试者，其中所述传染病由病毒引起，该病毒来自黄病毒科或副黏病毒科。
• POLYMERIC COATINGS AND METHODS FOR FORMING THEM
  申请人：Meagher Laurence

  公开号：US20080045686A1

  公开（公告）日：2008-02-21

  The present invention relates to a controllable polymeric surface coating including a macromolecule, which is covalently bound to the surface of a substrate, the macromolecule including a plurality of polymerisation initiators and a plurality of surface binding groups; and pendant polymers grafted from at least some of the polymerisation initiators.

  本发明涉及一种可控的聚合物表面涂层，包括一种大分子，该大分子与基底表面共价结合，该大分子包括多个聚合引发剂和多个表面结合基团；并且从至少一些聚合引发剂上生长的悬挂聚合物。
• Potential antileukemic and immunosuppressive drugs. Preparation and in vitro pharmacological activity of some 2,1,3-benzoxadiazoles (benzofurazans) and their N-oxides (benzofuroxans)
  作者：P. B. Ghosh、Michael W. Whitehouse

  DOI：10.1021/jm00308a027

  日期：1968.3
• Dual Catalytic Synthesis of Antiviral Compounds Based on Metallocarbene–Azide Cascade Chemistry
  作者：Bren Jordan P. Atienza、Lionel D. Jensen、Sarah L. Noton、Anil Kumar Victoria Ansalem、Tom Hobman、Rachel Fearns、David J. Marchant、F. G. West

  DOI：10.1021/acs.joc.8b00222

  日期：2018.7.6

  Aryl azides trap ortho-metallocarbene intermediates to generate indolenones possessing a reactive C-acylimine moiety, which can react with added indole nucleophiles to afford the 2-(3-indolyl)indolin-3-one scaffold found in the antiviral natural product isatisine A. This overall process occurs through a dual catalytic sequence at room temperature. Redox activation of the Cu(OTf)(2) precatalyst by indole results in catalytically competent Cu(I) required for azide-metal-locarbene coupling. The Bronsted acid that is also formed from Cu(OTf)(2) reduction is responsible for catalysis of the C-C bond-forming indole addition step. This modular, procedurally simple method allows for rapid assembly of bis(indole) libraries, several of which proved to have anti-infective activity against respiratory syncytial virus and Zika virus.
• TREATMENT OF INFECTIOUS DISEASE
  申请人：The Governors of the University of Alberta

  公开号：EP3774729A1

  公开（公告）日：2021-02-17