4-(2-trifluoromethyl-benzoimidazol-1-yl)-phenol | 134275-27-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 4-(2-trifluoromethyl-benzoimidazol-1-yl)-phenol
• 英文别名: 4-[2-(Trifluoromethyl)benzimidazol-1-yl]phenol
• CAS: 134275-27-7
• 化学式: C₁₄H₉F₃N₂O
• 分子量: 278.233
• InChiKey: GWPZGJFGQJDHMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  38
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Benzimidazole compounds and their use as estrogen agonists/antagonists
  申请人：——

  公开号：US20040002524A1

  公开（公告）日：2004-01-01

  This invention relates to compounds, in particular benzimidazoles, that are useful as estrogen agonists and/or antagonists and pharmaceutical uses thereof. The present invention also relates to benzimidazoles that are selective for the ER&bgr; receptor and pharmaceutical uses thereof.

  本发明涉及一种化合物，特别是苯并咪唑，其作为雌激素激动剂和/或拮抗剂具有用途，并且具有药用用途。本发明还涉及对ER&bgr;受体具有选择性的苯并咪唑及其药用用途。
• BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS ESTROGEN AGONISTS/ANTAGONISTS
  申请人：Pfizer Products Inc.

  公开号：EP1517897A2

  公开（公告）日：2005-03-30
• [EN] BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS ESTROGEN AGONISTS/ANTAGONISTS<br/>[FR] COMPOSES BENZIMIDAZOLE ET LEURS UTILISATIONS EN TANT QU'AGONISTES/ANTAGONISTES DES OESTROGENES
  申请人：PFIZER PROD INC

  公开号：WO2004000817A2

  公开（公告）日：2003-12-31

  Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein at least one of R?1 and R2¿ is a group of the formula (II), wherein R?7, R8, R10 and R11¿ are each independently hydrogen; hydroxy; (C¿1?-C6) alkyl; (C1-C6) alkoxy; or halogen; R?9¿ is hydroxy; (C¿1?-C6) alkoxy; (C1-C6)alkoxycarbonyloxy; (C1-C6)alkylcarbonyloxy; (C3-C8)cycloalkoxy; (C4-C8)cycloalkenyloxy; or (C6-C12) aryloxy; are useful as estrogen agonists and/or antagonists and pharmaceutical uses thereof.