(1S,5R,13S,17R)-4-(2-Phenylethyl)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-10-ol | 722450-07-9

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: (1S,5R,13S,17R)-4-(2-Phenylethyl)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-10-ol
• 英文别名: (4R,4aR,7aS,12bS)-3-(2-phenylethyl)-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-9-ol
• CAS: 722450-07-9
• 化学式: C₂₄H₂₇NO₂
• 分子量: 361.5
• InChiKey: JZVQXSYNZPVRTQ-FPRSRYDQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Treatment of dermatological conditions via neuromodulation
  申请人：Palo Alto Investors

  公开号：US11383084B2

  公开（公告）日：2022-07-12

  Methods for treating a subject for a dermatological condition are provided. Aspects of the invention include administering an effective amount of a neuromodulatory agent to a subject to treat the subject for the dermatological condition. Also provided are compositions, kits and systems for practicing the subject methods.

  本发明提供了治疗受试者皮肤病的方法。本发明的各个方面包括向受试者施用有效量的神经调节剂，以治疗受试者的皮肤病。本发明还提供了用于实施上述方法的组合物、试剂盒和系统。
• CLOSTRIDIAL NEUROTOXIN FORMULATIONS AND USE
  申请人：Bonti, Inc.

  公开号：EP3644971A1

  公开（公告）日：2020-05-06
• NEUROTOXIN COMPOSITIONS FOR USE IN IMPROVING LUNG FUNCTION
  申请人：Bonti, Inc.

  公开号：EP3703732A1

  公开（公告）日：2020-09-09
• Treatment of Dermatological Conditions via Neuromodulation
  申请人：Palo Alto Investors

  公开号：US20180311499A1

  公开（公告）日：2018-11-01

  Methods for treating a subject for a dermatological condition are provided. Aspects of the invention include administering an effective amount of a neuromodulatory agent to a subject to treat the subject for the dermatological condition. Also provided are compositions, kits and systems for practicing the subject methods.
• [EN] CLOSTRIDIAL NEUROTOXIN FORMULATIONS AND USE<br/>[FR] FORMULATIONS DE NEUROTOXINE CLOSTRIDIALE ET UTILISATION
  申请人：BONTI INC

  公开号：WO2019005773A1

  公开（公告）日：2019-01-03

  Disclosed herein are compositions and methods for use in neurotoxin treatments.