| 1417621-37-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• CAS: 1417621-37-4
• 化学式: C₁₅H₁₆N₂O₃
• 分子量: 272.304
• InChiKey: RFHQYEWWOSUZKC-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 三氯氧磷 作用下， 反应 8.0h， 以83%的产率得到
  参考文献：
  名称：

  Synthesis and properties of derivatives of pyrimidin-5-ylpropanoic acids and 8-aryl-4-methyl- and 4,6-dimethyl-2-phenyl-5,6,7,8-tetrahydropyrido-[2,3-d]pyrimidin-7-ones

  摘要：

  Proceeding from 3-(4-methyl-6-oxo-2-phenyl-1,6-dihydro-5-pyrimidinyl)propanoic and 2-methylpropanoic acids by successive reactions of chlorination, amination, and heterocyclization 4-amino-substituted pyrimidines were synthesized: 5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine derivatives and 4-methyl-2-phenyl-5,6-dihydrobenzo[4',5']imidazo[2',1':6,1]pyrido[2,3-d]pyrimidine which we had previously obtained by alternative method. Antibacterial properties of the synthesized compounds were studied.

  DOI：

  10.1134/s1070428015050218

文献信息

• Synthesis of tetra- and pentaaza heterocyclic systems and benzimidazo[1,2-c]quinazoline derivatives
  作者：A. A. Harutyunyan

  DOI：10.1134/s1070428014010187

  日期：2014.1

  5,6-Dihydropyrimido[5′,4′: 5,6]pyrido[1,2-a]benzimidazole and pyrimido[4′,5′: 4,5]pyrimido[1,6-a]-benzimidazole derivatives were synthesized starting from 3-[4-hydroxy-6-methyl(hydroxy)-2-phenylpyrimidin-5-yl]propanoic and 4-hydroxy-2-phenylpyrimidine-5-carboxylic acids. New 6-sulfanyl-substituted benzimidazo-[1,2-c]quinazolines were also prepared.

  5,6-二氢嘧啶基[5'，4'：5,6]吡啶基[1,2- a ]苯并咪唑和嘧啶基[4'，5'：4,5]嘧啶基[1,6- a ]-苯并咪唑衍生物是从3- [4-羟基-6-甲基（羟基）-2-苯基嘧啶-5-基]丙酸和4-羟基-2-苯基嘧啶-5-羧酸开始合成。还制备了新的6-硫烷基取代的苯并咪唑-[1,2- c ]喹唑啉。
• Synthesis of tetra- and pentaazaheterocyclic systems and benzimidazo[1,2-c]quinazoline derivatives
  作者：A. A. Arutyunyan

  DOI：10.1134/s1070428014020195

  日期：2014.2

  Starting with 5-carboxy-4-hydroxy-2-phenylpyrimidine and 4-hydroxy-6-methyl(hydroxy)-2-phenylpyrimidinyl-5-propanoic acids derivatives of two heterocyclic systems, benzimidazopyrido- and pyrimidopyrimidine, were synthesized. Synthesis of new S-substituted benzimidazo[1,2-c]quinazolines was also carried out.
• One-step synthesis of pyrido[2,3-d]pyrimidines, amides, and benzoxazolylethylpyrimidine by condensation of substituted 3-(2-phenylpyrimidin-5-yl)propanoic acids with aromatic amines in polyphosphoric acid
  作者：A. A. Harutyunyan、H. A. Panosyan、S. G. Chishmarityan、R. A. Tamazyan、A. G. Ayvazyan

  DOI：10.1134/s1070428015030112

  日期：2015.3

  Depending on the reactant structure, reactions of substituted 3-(2-phenylpyrimidin-5-yl)propanoic acids with 2-aminopyridine, p-toluidine, and 2-aminophenol in polyphosphoric acid afforded the corresponding N-(pyridin-2-yl)propanamides, 5-[2-(benzoxazol-2-yl)ethyl]pyrimidine, and pyrido[2,3-d]pyrimidinones.