N-hydroxy-2-[2-[4-(trifluoromethyl)phenyl]propan-2-ylamino]pyrimidine-5-carboxamide | 1375465-92-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-hydroxy-2-[2-[4-(trifluoromethyl)phenyl]propan-2-ylamino]pyrimidine-5-carboxamide
• CAS: 1375465-92-1
• 化学式: C₁₅H₁₅F₃N₄O₂
• 分子量: 340.3
• InChiKey: MBRUFEUOQFTVFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  87.1
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• HDAC INHIBITORS FOR THE TREATMENT OF DIABETIC PERIPHERAL NEUROPATHY
  申请人：ACETYLON PHARMACEUTICALS, INC.

  公开号：US20170114023A1

  公开（公告）日：2017-04-27

  The invention relates to HDAC inhibitors for use in the treatment of diabetic peripheral neuropathy in a subject in need thereof. Also provided herein are methods for treating diabetic peripheral neuropathy in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an HDAC inhibitor.

  该发明涉及用于治疗需要的患者的糖尿病性周围神经病的HDAC抑制剂。本文还提供了一种治疗糖尿病性周围神经病的方法，包括向患者施用HDAC抑制剂的治疗有效剂量。
• PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF
  申请人：van Duzer John H.

  公开号：US20120121502A1

  公开（公告）日：2012-05-17

  The present invention relates to novel pyrimidine hydroxy amide compounds, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.

  本发明涉及新型嘧啶羟基酰胺化合物，以及在抑制HDAC6和治疗与HDAC6相关的各种疾病、疾患或病情方面使用这些化合物的方法。
• HDAC inhibitors for the treatment of diabetic peripheral neuropathy
  申请人：ACETYLON PHARMACEUTICALS, INC.

  公开号：US10040769B2

  公开（公告）日：2018-08-07

  The invention relates to HDAC inhibitors for use in the treatment of diabetic peripheral neuropathy in a subject in need thereof. Also provided herein are methods for treating diabetic peripheral neuropathy in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an HDAC inhibitor.

  本发明涉及 HDAC 抑制剂，用于治疗有需要的受试者的糖尿病周围神经病变。本文还提供了治疗有需要的受试者的糖尿病周围神经病变的方法，包括给受试者施用治疗有效量的 HDAC 抑制剂。
• PYRIMIDINE HYDROXY AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF
  申请人：Acetylon Pharmaceuticals

  公开号：US20140142104A1

  公开（公告）日：2014-05-22

  The present invention relates to novel pyrimidine hydroxy amide compounds, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
• IMPAIRMENT OF THE LARGE RIBOSOMAL SUBUNIT PROTEIN RPL24 BY DEPLETION OR ACETYLATION
  申请人：Buck Institute for Research on Aging

  公开号：US20150359794A1

  公开（公告）日：2015-12-17

  Provided herein are compositions of histone deacetylase (HDAC) inhibitors for the treatment of cancers overexpressing the large ribosomal subunit protein 24 (RPL24) in a subject in need thereof. Provided herein are methods for treating RPL24-overexpressing cancers in a subject in need thereof, comprising administering to the subject an effective amount of an HDAC inhibitor. Also provided herein are methods for inhibiting the viability of an RPL24-overexpressing cancer cell with an HDAC inhibitor. Also provided herein are methods for assessing the efficacy of an HDAC inhibitor against a cancer.