4-Ethyl-5-phenylpyrimidin-2-amine | 1549808-73-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-Ethyl-5-phenylpyrimidin-2-amine
• CAS: 1549808-73-2
• 化学式: C₁₂H₁₃N₃
• 分子量: 199.25
• InChiKey: OZMWQNXKYWHOAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  51.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PHENYL -C-OXADIAZOLE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE PRODUCTION COMBINATION THERAPY
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2809321A1

  公开（公告）日：2014-12-10
• [EN] PHENYL -C-OXADIAZOLE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE PRODUCTION COMBINATION THERAPY<br/>[FR] DÉRIVÉS DE PHÉNYL-C-OXADIAZOLE UTILISÉS DANS UN TRAITEMENT COMBINÉ COMME INHIBITEURS DE LA PRODUCTION DE LEUCOTRIÈNES
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2013113799A1

  公开（公告）日：2013-08-08

  The present invention relates to combination therapy using compound of formula (I): or pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined herein and an additional pharmaceutically active agent. The invention also relates to pharmaceutical compositions comprising these combinations, and methods of using these combinations in the treatment of various diseases and disorders.