<2,6-dimethyl-2,5-bis(methoxycarbonyl)-1,4-dihydropyridine>-4-spiro-3'-(5'-nitro-2',3'-dihydro-1'-benzothiophene 1'-oxide) | 125764-72-9

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: <2,6-dimethyl-2,5-bis(methoxycarbonyl)-1,4-dihydropyridine>-4-spiro-3'-(5'-nitro-2',3'-dihydro-1'-benzothiophene 1'-oxide)
• CAS: 125764-72-9
• 化学式: C₁₈H₁₈N₂O₇S
• 分子量: 406.416
• InChiKey: QDTGUIATMCUVCZ-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  dimethyl 2,6-dimethyl-4-<2-(methylsulfinyl)-5-nitrophenyl>pyridine-3,5-dicarboxylate 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 以32.3%的产率得到<2,6-dimethyl-2,5-bis(methoxycarbonyl)-1,4-dihydropyridine>-4-spiro-3'-(5'-nitro-2',3'-dihydro-1'-benzothiophene 1'-oxide)
  参考文献：
  名称：

  Synthesis, pharmacological effects, and conformation of 4,4-disubstituted 1,4-dihydropyridines

  摘要：

  4,4-Disubstituted 1,4-dihydropyridines are synthesized by intramolecular addition of sulfinyl carbanions to pyridines. These disubstituted derivatives show a loss of Ca antagonistic potency of up to three powers of 10 both in vitro on aortic rings and in vivo on anaesthetized dogs as compared to examples that are monosubstituted at the 4-position of the DHP ring. As the X-ray structure shows, the 4-aryl substituent is present not in the accustomed axial conformation, but in an equatorial one. This dramatic change in conformation could be the reason for the major loss of activity and would indicate the need for axial conformation of the aryl residue in pharmacologically active 1,4-dihydropyridines. The change in conformation was also confirmed by quantum chemical calculations (AM1).

  DOI：

  10.1021/jm00167a021