N-[2-(3,6-Dihydro-2H-thiopyran-4-yl)-ethyl]-2-phenyl-acetamide | 152169-85-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[2-(3,6-Dihydro-2H-thiopyran-4-yl)-ethyl]-2-phenyl-acetamide
• CAS: 152169-85-2
• 化学式: C₁₅H₁₉NOS
• 分子量: 261.388
• InChiKey: BYIYVOPGZLGFKZ-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  N-[2-(3,6-Dihydro-2H-thiopyran-4-yl)-ethyl]-2-phenyl-acetamide 在 phosphorus pentoxide 作用下， 以 苯 为溶剂， 生成 8-Benzyl-3,4,5,6-tetrahydro-1H-thiopyrano[3,4-c]pyridine
  参考文献：
  名称：

  Anomalous Cyclization in an Attempted Synthesis of the '7-Thiomorphinan', System

  摘要：

  The acid catalyzed cyclization of 8-benzyl-3,4,5,6,7,8-hexahydro-1H-thiopyrano[3,4-c]pyridine hydrochloride (10) did not furnish the expected the '7-thiomorphinan' (11) but 4-(2-mercaptoethyl)-1,2,3,5,10,10a-hexahydrobenzo[g]quinoline (12) instead. The synthesis of 10 and the mechanism of formation of 12 are described.

  DOI：

  10.3987/com-93-s(t)142
• 作为产物：
  描述：

  (3,6-Dihydro-2H-thiopyran-4-yl)-acetonitrile 在 lithium aluminium tetrahydride 、 sodium carbonate 作用下， 生成 N-[2-(3,6-Dihydro-2H-thiopyran-4-yl)-ethyl]-2-phenyl-acetamide
  参考文献：
  名称：

  Anomalous Cyclization in an Attempted Synthesis of the '7-Thiomorphinan', System

  摘要：

  The acid catalyzed cyclization of 8-benzyl-3,4,5,6,7,8-hexahydro-1H-thiopyrano[3,4-c]pyridine hydrochloride (10) did not furnish the expected the '7-thiomorphinan' (11) but 4-(2-mercaptoethyl)-1,2,3,5,10,10a-hexahydrobenzo[g]quinoline (12) instead. The synthesis of 10 and the mechanism of formation of 12 are described.

  DOI：

  10.3987/com-93-s(t)142