[2-(1-pyrrolidyl)ethyl]cyclopentadienyllithium | 261638-45-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: [2-(1-pyrrolidyl)ethyl]cyclopentadienyllithium
• 英文别名: cyclo-C4H8NC2H4C5H4Li
• CAS: 261638-45-3
• 化学式: C₁₁H₁₆N*Li
• 分子量: 169.196
• InChiKey: QEIXFSRVEPDIMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.95
• 重原子数：
  13.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  3.24
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  盐酸 、 [2-(1-pyrrolidyl)ethyl]cyclopentadienyllithium 、 三氯一茂钛 以 四氢呋喃 为溶剂， 以71.8%的产率得到
  参考文献：
  名称：

  A new series of titanocene dichloride derivatives bearing cyclic alkylammonium groups: Assessment of their cytotoxic properties

  摘要：

  Ten new water soluble titanocene dichloride derivatives have been synthesized and characterized and their cytotoxicities against the human lung cancer cell line A549 have been assessed. The potencies of the compounds vary greatly, but dicationic 3-picolylium and 4-picolylium compounds exhibit IC50 values that are unusually low for this class of compounds. In view of their potency against A549 cells, three of the new complexes were tested further on additional human cell lines including the small cell lung cancer cell line H69, the widely used cervical carcinoma cell line HeLa, the ovarian carcinoma cell line A2780 and its cisplatin resistant derivative A2780/CP. All three compounds exhibited potencies in all cell lines comparable to or better than those observed with the A549 cells, while one complex is actually more potent than cisplatin for HeLa cells. (c) 2007 Published by Elsevier B.V.

  DOI：

  10.1016/j.jorganchem.2007.04.024
• 作为产物：
  描述：

  N-(2-氯乙基)吡咯烷盐酸盐 、 sodium cyclopentadienide 在 甲基锂 作用下， 以 四氢呋喃 、 乙醚 、 正己烷 为溶剂， 反应 0.5h， 生成 [2-(1-pyrrolidyl)ethyl]cyclopentadienyllithium
  参考文献：
  名称：

  A new series of titanocene dichloride derivatives bearing cyclic alkylammonium groups: Assessment of their cytotoxic properties

  摘要：

  Ten new water soluble titanocene dichloride derivatives have been synthesized and characterized and their cytotoxicities against the human lung cancer cell line A549 have been assessed. The potencies of the compounds vary greatly, but dicationic 3-picolylium and 4-picolylium compounds exhibit IC50 values that are unusually low for this class of compounds. In view of their potency against A549 cells, three of the new complexes were tested further on additional human cell lines including the small cell lung cancer cell line H69, the widely used cervical carcinoma cell line HeLa, the ovarian carcinoma cell line A2780 and its cisplatin resistant derivative A2780/CP. All three compounds exhibited potencies in all cell lines comparable to or better than those observed with the A549 cells, while one complex is actually more potent than cisplatin for HeLa cells. (c) 2007 Published by Elsevier B.V.

  DOI：

  10.1016/j.jorganchem.2007.04.024

文献信息

• Donor-Ligand-Substituted Cyclopentadienylchromium(III) Complexes:  A New Class of Alkene Polymerization Catalyst. 1. Amino-Substituted Systems
  作者：A. Döhring、J. Göhre、P. W. Jolly、B. Kryger、J. Rust、G. P. J. Verhovnik

  DOI：10.1021/om990643r

  日期：2000.2.1

  Me2NC2H4C5Me4Li reacts with Cr(THF)(3)Cl-3 to give (eta(1):eta(5)-Me2NC2H4C5Me4) CrCl2, in which the complexation of the N-donor atom to the metal atom has been confirmed by X-ray crystallography. A series of related compounds, e.g. (eta(1):eta(5)-cyclo-C4H8NSiMe2OSiMe2C5H4)-CrCl2 has been prepared by varying the substituents on the organic ligand. Further reaction with organomagnesium reagents leads to formation of the corresponding dialkyl-Cr complexes. Related species have been prepared containing imine-, alkoxy-, and alkylthiosubstituted cyclopentadienyl groups as well as the C-donor ligand tetramethylimidazol-2-ylidene. Treatment of these compounds with methylalumoxane (MAO) leads to the formation of highly active catalysts for the oligomerization, polymerization, and copolymerization of ethylene.