(2-{N-[4-(prop-2-en-1-yloxy)pyridin-2-ylmethyl]-N-(pyridin-2-ylmethyl)amino}ethyl)carbamic acid tert-butyl ester | 1233320-11-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (2-{N-[4-(prop-2-en-1-yloxy)pyridin-2-ylmethyl]-N-(pyridin-2-ylmethyl)amino}ethyl)carbamic acid tert-butyl ester
• CAS: 1233320-11-0
• 化学式: C₂₂H₃₀N₄O₃
• 分子量: 398.505
• InChiKey: LEZNNJNTUKQLCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.57
• 重原子数：
  29.0
• 可旋转键数：
  10.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  76.58
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  (2-{N-[4-(prop-2-en-1-yloxy)pyridin-2-ylmethyl]-N-(pyridin-2-ylmethyl)amino}ethyl)carbamic acid tert-butyl ester 在 三氟乙酸 、 sodium hydroxide 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 1.25h， 以99%的产率得到N-[4-(prop-2-en-1-yloxy)pyridin-2-ylmethyl]-N-(pyridin-2-ylmethyl)ethylenediamine
  参考文献：
  名称：

  Thermo-responsive extraction of cadmium(II) ion with TPEN-NIPA gel. Effect of the number of polymerizable double bond toward gel formation and the extracting behavior

  摘要：

  N,N,N',N'-(Tetrakis-2-pyridylmethyl)ethylenediamine (TPEN) derivatives bearing the different number (1-4) of a double bond moiety oil the pyridine ring are synthesized and subjected to copolymerization with N-isopropylacrylamide in the presence of AIBN The obtained poly(TPEN-NIPA) gels show thermoresponsive swelling/shrinking behaviors and are employed for the extraction of cadmium(II) ion from the aqueous solution to examine the relationship of the gel characteristics and the extraction per for Malice The polymer gels composed of the TPEN derivative bearing three or four double bonds exhibit temperature-dependent change of swelling and shrinking in water These gels extract Cd-II ion efficiently from the aqueous solution in the swelling state at 5 degrees C, while little extraction was observed at 45 degrees C with shrinking (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tet.2009.12.047
• 作为产物：
  描述：

  tert-butyl (2-((pyridin-2-ylmethyl)amino)ethyl)carbamate 、 2-chloromethyl-4-(prop-2-en-1-yloxy)pyridine hydrochloride 在 十六烷基三甲基氯化铵 、 potassium iodide 、 sodium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 48.0h， 以85%的产率得到(2-{N-[4-(prop-2-en-1-yloxy)pyridin-2-ylmethyl]-N-(pyridin-2-ylmethyl)amino}ethyl)carbamic acid tert-butyl ester
  参考文献：
  名称：

  Thermo-responsive extraction of cadmium(II) ion with TPEN-NIPA gel. Effect of the number of polymerizable double bond toward gel formation and the extracting behavior

  摘要：

  N,N,N',N'-(Tetrakis-2-pyridylmethyl)ethylenediamine (TPEN) derivatives bearing the different number (1-4) of a double bond moiety oil the pyridine ring are synthesized and subjected to copolymerization with N-isopropylacrylamide in the presence of AIBN The obtained poly(TPEN-NIPA) gels show thermoresponsive swelling/shrinking behaviors and are employed for the extraction of cadmium(II) ion from the aqueous solution to examine the relationship of the gel characteristics and the extraction per for Malice The polymer gels composed of the TPEN derivative bearing three or four double bonds exhibit temperature-dependent change of swelling and shrinking in water These gels extract Cd-II ion efficiently from the aqueous solution in the swelling state at 5 degrees C, while little extraction was observed at 45 degrees C with shrinking (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tet.2009.12.047