1-Methyl-4-thiothymin | 25307-97-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-Methyl-4-thiothymin
• 英文别名: 1,5-Dimethyl-4-sulfanylidenepyrimidin-2-one
• CAS: 25307-97-5
• 化学式: C₆H₈N₂OS
• 分子量: 156.208
• InChiKey: INLXBFLNJNFHJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  64.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• 4'-ALLENE-SUBSTITUTED NUCLEOSIDE DERIVATIVES
  申请人：Qiu Yao-Ling

  公开号：US20100074889A1

  公开（公告）日：2010-03-25

  The present invention discloses compounds of formula (I), or its β-L enantiomer, or a pharmaceutically acceptable salt, ester, stereoisomer, tautomer, solvate, prodrug, or combination thereof: which inhibit, preventing or treating abnormal cellular proliferation and/or a viral infection, particularly by HIV, HCV or HBV. Consequently, the compounds of the present invention interfere with the replication cycle of a virus and are also useful as antiviral agents, or interfere with host cellular biochemical process and are also useful as antiproliferative agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from viral infection and/or cell proliferation. The invention also relates to methods of treating a viral infection and/or cell proliferation in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention relates to novel antiviral/anti-proliferative compounds represented herein above, pharmaceutical compositions comprising such compounds, and methods for the treatment or prophylaxis of viral infection in a subject in need of such therapy with said compounds.
• US8163707B2
  申请人：——

  公开号：US8163707B2

  公开（公告）日：2012-04-24
• US9732110B2
  申请人：——

  公开号：US9732110B2

  公开（公告）日：2017-08-15