2,3-Dihydroxypropyl 2-methylprop-2-enoate--methyl 2-methylprop-2-enoate (1/1) | 50450-03-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 2,3-Dihydroxypropyl 2-methylprop-2-enoate--methyl 2-methylprop-2-enoate (1/1)
• 英文别名: 2,3-dihydroxypropyl 2-methylprop-2-enoate;methyl 2-methylprop-2-enoate
• CAS: 50450-03-8
• 化学式: C12H20O6
• 分子量: 260.28
• InChiKey: WCHGBBFQLYNWIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.19
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Composite intraocular lens and method of manufacture
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0492126A2

  公开（公告）日：1992-07-01

  The new intraocular lens of the present invention is a one-piece composite lens having a soft, foldable central optic region and a hard, non-foldable outer peripheral region making up the haptics or legs of the intraocular lens. The soft, central optic portion of the lens is typically manufactured from a material capable of being folded so that the intraocular lens can be inserted through a small incision on the order of 3 to 4 mm. The hard haptic portion of the lens provides support for the lens in the eye after insertion and unfolding of the lens. The relatively rigid plastic lends support to the entire lens structure after its insertion into the posterior chamber of the eye, and tends to help stabilize the position of the lens after insertion and the closure of the incision. A preferred material of the soft optical region being a poly(hydroxyethyl methacrylate) or pHEMA or a copolymer thereof such as HEMA and 6-hydroxyhexyl methacrylate (HOHEXMA) or p(HEMA-co-HOHEXMA). The preferred material of the hard haptic region being made from a relatively hard plastic, such as (polymethyl methacrylate) or PMMA, or a copolymer thereof.

  本发明的新型眼内透镜是一种一体式复合透镜，具有柔软、可折叠的中央光学区和坚硬、不可折叠的外周区，构成眼内透镜的触觉或镜腿。镜片柔软的中央光学部分通常由可折叠的材料制成，这样眼内透镜就可以通过一个约 3 至 4 毫米的小切口插入。晶状体的硬质触觉部分可在晶状体插入和展开后为眼内的晶状体提供支撑。镜片插入眼球后腔后，相对坚硬的塑料可为整个镜片结构提供支撑，并有助于稳定镜片插入和关闭切口后的位置。软光学区的首选材料是聚甲基丙烯酸羟乙酯或 pHEMA 或其共聚物，如 HEMA 和 6-羟基己基甲基丙烯酸酯（HOHEXMA）或 p（HEMA-co-HOHEXMA）。硬触感区的材料最好由相对较硬的塑料制成，如（聚甲基丙烯酸甲酯）或 PMMA 或其共聚物。
• JPS06197348A
  申请人：——

  公开号：JPS06197348A

  公开（公告）日：1986-05-15
• JPS6197348A
  申请人：——

  公开号：JPS6197348A

  公开（公告）日：1986-05-15
• US5217491A
  申请人：——

  公开号：US5217491A

  公开（公告）日：1993-06-08
• US5326506A
  申请人：——

  公开号：US5326506A

  公开（公告）日：1994-07-05