5α,6α-epoxycholestanol | 97100-48-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 5α,6α-epoxycholestanol
• 英文别名: 5α, 6α-epoxycholestan-3β-ol；5β, 6β-epoxycholestan-3β-ol；Cholesterol 5α,6α-epoxide；cholesterol 5β,6β-epoxide；5α,6α-Epoxycholestanol；5,6-epoxy cholesterol；cholesterol epoxide；Cholesterol oxide；(4aR,5aS,6aS,6bS,9R,9aR,11aS,11bR)-9a,11b-dimethyl-9-((R)-6-methylheptan-2-yl)hexadecahydrocyclopenta[1,2]phenanthro[8a,9-b]oxiren-3-ol；(1S,2R,7R,9S,11S,12S,15R,16R)-2,16-dimethyl-15-[(2R)-6-methylheptan-2-yl]-8-oxapentacyclo[9.7.0.02,7.07,9.012,16]octadecan-5-ol
• CAS: 97100-48-6
• 化学式: C₂₇H₄₆O₂
• 分子量: 402.661
• InChiKey: PRYIJAGAEJZDBO-OQFIMBQPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5α,6α-epoxycholestanol 在 4-二甲氨基吡啶 、 二叔丁基过氧化物 、 四丁基氟化铵 、 三正丁基氢锡 作用下， 以 乙腈 为溶剂， 反应 9.0h， 生成 5α,6α-epoxycholestane
  参考文献：
  名称：

  Smooth and efficient deoxygenation of secondary alcohols. A general procedure for the conversion of ribonucleosides to 2'-deoxynucleosides

  摘要：

  DOI：

  10.1021/ja00394a033

文献信息

• Functional associative coatings for nanoparticles
  申请人：Hainfeld James F.

  公开号：US20080089836A1

  公开（公告）日：2008-04-17

  Described herein are nanoparticles that are coated with a bilayer of molecules formed from surface binding molecules and amphiphatic molecules. The bilayer coating self assembles on the nanoparticles from readily available materials/molecules. The modular design of the bilayer coated nanoparticles provides a means for readily and efficiently optimizing the properties of the bilayer coated nanoparticle compositions. Also described herein are uses of such nanoparticles in medicine, laboratory techniques, industrial and commerical applications.

  本文描述了一种纳米颗粒，其表面涂覆有由表面结合分子和两亲分子形成的双层分子层。该双层涂层可以自组装在纳米颗粒上，使用易得的材料/分子。双层涂层纳米颗粒的模块化设计提供了一种方便和高效地优化其性质的方法。此外，本文还描述了这种纳米颗粒在医学、实验室技术、工业和商业应用中的用途。
• CONDUCTIVE COMPOSITION, CONDUCTIVE COMPOSITION PRODUCTION METHOD, ANTI-STATIC RESIN COMPOSITION AND ANTISTATIC RESIN FILM
  申请人：Shin-Etsu Polymer Co. Ltd.

  公开号：EP2957597A1

  公开（公告）日：2015-12-23

  [Purpose] To form a transparent conductive film with fewer problems originating from amine compounds by using a conductive composition stably and pseudo-solubly dispersed in a solvent consisting mainly of an organic solvent. [Solution] This invention relates to: a conductive composition which is pseudo-solubly dispersed in a solvent consisting mainly of an organic solvent and which contains (a) a π-conjugated conductive polymer, (b) polyanions doping the π-conjugated conductive polymer (a), and (c) a reaction product of those anions of the polyanions (b) that were not needed for doping, and an oxirane group- and/or oxetane group-containing organic compound; a production method of said conductive composition; an anti-static resin composition formed by mixing said conductive composition and a resin solution dissolved in an organic solvent; and antistatic resin film formed by curing said anti-static resin composition.

  [目的]通过使用稳定地、假溶解地分散在主要由有机溶剂组成的溶剂中的导电组合物， 形成一种由胺化合物引起的问题较少的透明导电膜。 [解决方案] 本发明涉及一种在主要由有机溶剂组成的溶剂中假溶解分散的导电组合物，该导电组合物包含 (a) π-共轭导电聚合物，(b) 掺杂 π-共轭导电聚合物 (a) 的多阴离子，(c) 不需要掺杂的多阴离子 (b) 的阴离子与环氧乙烷基团和/或含环氧乙烷基团的有机化合物的反应产物；所述导电组合物的生产方法；通过混合所述导电组合物和溶解在有机溶剂中的树脂溶液形成的抗静电树脂组合物；以及通过固化所述抗静电树脂组合物形成的抗静电树脂薄膜。
• CURABLE ANTISTATIC ORGANOPOLYSILOXANE COMPOSITION AND ANTISTATIC SILICONE FILM
  申请人：Shin-Etsu Polymer Co. Ltd.

  公开号：EP2982712A1

  公开（公告）日：2016-02-10

  [Purpose] To provide a curable antistatic organopolysiloxane composition capable of alleviating problems originating from amine compounds and problems originating from water, and to provide an antistatic silicone film formed by curing said composition. [Solution] This invention relates to: a curable antistatic organopolysiloxane composition which contains (I) a conductive polymer composition which is pseudo-solubly dispersed in a solvent consisting mainly of an organic solvent and which contains (a) a π-conjugated conductive polymer, (b) polyanions doping the n-conjugated conductive polymer (a), and (c) a reaction product of those anions of the polyanions (b) that were not needed for doping, and an oxirane group- and/or oxetane group-containing organic compound, and (II) a curable organopolysiloxane composition; and an antistatic silicone film which is formed by supplying said composition onto a substrate and curing the same.

  [目的]提供一种可固化的抗静电有机聚硅氧烷组合物，该组合物能够缓解源于胺化合物的问题和源于水的问题，并提供一种通过固化所述组合物形成的抗静电硅薄膜。 [解决方案] 本发明涉及一种可固化的抗静电有机聚硅氧烷组合物，该组合物包含 (I) 一种导电聚合物组合物，该导电聚合物组合物假溶解地分散在主要由有机溶剂组成的溶剂中，该导电聚合物组合物包含 (a) π-共轭导电聚合物、(c) 不需要掺杂的多阴离子(b)的阴离子与含环氧乙烷基团和/或环氧乙烷基团的有机化合物的反应产物，以及 (II) 可固化的有机聚硅氧烷组合物；以及一种抗静电硅薄膜，它是通过将上述组合物涂在基底上并固化而形成的。
• CANNABINOID-CONTAINING COMPOSITIONS IN THE FORM OF SPHERES OR SPHERE-LIKE PARTICLES, METHODS FOR THEIR PREPARATION, AND THERAPEUTIC APPLICATIONS
  申请人：Landsteiner Scientific S.A. de C.V.

  公开号：EP3769752A1

  公开（公告）日：2021-01-27

  Pharmaceutical compositions and or formulations are in the form of spheres, or sphere-like particles. The pharmaceutical compositions include at least one isolated Cannabinoid or mixtures of at least two isolated Cannabinoid-elements obtained from raw or pre-treated vegetable material of Cannabis spp. (i.e. any species of Cannabis) or any synthetic or any semi-synthetic cannabinoid-mimicking compounds, that are formulated in encapsulated forms. Different routes of administration and desired therapeutic effects can be achieved with variations of the spheres and sphere-like particles.

  药物组合物和制剂为球状或球状颗粒。药物组合物包括至少一种分离的大麻素或至少两种分离的大麻素的混合物，这些大麻素或大麻素混合物取自大麻属植物（即任何种类的大麻）的原料或预处理过的植物材料，或任何合成或任何半合成的大麻素模拟化合物，并以封装形式配制。不同的球状和球状颗粒可以实现不同的给药途径和所需的治疗效果。
• Liposomal formulation of nonglycosidic ceramides and uses thereof
  申请人：LUDWIG INSTITUTE FOR CANCER RESEARCH LTD.

  公开号：US10039715B2

  公开（公告）日：2018-08-07

  The invention provides liposomes containing nonglycosidic ceramides within their bilayers, and compositions thereof. These liposomes activate murine iNKT cells and induce dendritic cell (DC) maturation, both in vitro and in vivo at an efficacy that is comparable to their corresponding soluble nonglycosidic ceramides. Also provided are methods for treating diseases using the liposomes and compositions of the invention.

  本发明提供了在其双层内含有非糖苷类神经酰胺的脂质体及其组合物。这些脂质体可在体外和体内激活小鼠 iNKT 细胞并诱导树突状细胞（DC）成熟，其功效与相应的可溶性非糖苷神经酰胺相当。此外，还提供了使用本发明脂质体和组合物治疗疾病的方法。