4-bromo-3-pyridinyl 2,3,4-tri-O-acetyl-5-thio-β-D-xylopyranoside | 910649-50-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-bromo-3-pyridinyl 2,3,4-tri-O-acetyl-5-thio-β-D-xylopyranoside
• 英文别名: 4-bromo-3-pyridinyl 2,3,4-tri-O-acetyl-5-thio-beta-D-xylopyranoside；[(3S,4S,5R,6R)-4,5-diacetyloxy-6-(4-bromopyridin-3-yl)oxythian-3-yl] acetate
• CAS: 910649-50-2
• 化学式: C₁₆H₁₈BrNO₇S
• 分子量: 448.291
• InChiKey: HBBDZZGPHYPNMV-QKPAOTATSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  126
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  4-bromo-3-pyridinyl 2,3,4-tri-O-acetyl-5-thio-β-D-xylopyranoside 、 4-三氟甲基苯硼酸 以4-[4-(trifluoromethyl)phenyl]-3-pyridinyl 2,3,4-tri-O-acetyl-5-thio-β-D-xylopyranoside is obtained in the form of a white powder (yield=31%)的产率得到4-[4-(trifluoromethyl)phenyl]-3-pyridinyl 2,3,4-tri-O-acetyl-5-thio-β-D-xylo-pyranoside
  参考文献：
  名称：

  Novel Compounds Derived From 5-Thioxylose And Their Use In Therapeutics

  摘要：

  本发明涉及新颖的5-硫氧木糖化合物，优选为5-硫氧基吡喃糖衍生物，以及它们的制备过程和它们作为药物活性成分的用途，特别是用于治疗或预防血栓形成或心力衰竭。

  公开号：

  US20080293768A1

文献信息

• Derivatives of 5-Thioxylopyranose and Use of Same for Treatment
  申请人：Barberousse Veronique

  公开号：US20090182013A1

  公开（公告）日：2009-07-16

  The invention relates to new compounds of 5-thioxilose, preferably derivatives of the 5-thioxilopyranose type, and to a method for preparing the same and their use as the active ingredient of drugs mainly intended for treating or inhibiting thrombosis or heart failure or thromboembolic diseases.

  该发明涉及5-硫代木糖的新化合物，优选为5-硫代木糖吡喃糖类的衍生物，以及一种制备这些化合物的方法和它们作为药物活性成分的用途，主要用于治疗或抑制血栓形成、心力衰竭或血栓栓塞性疾病。
• Derivatives of 5-thioxylopyranose and use of same for treatment
  申请人：Laboratoires Fournier S.A.

  公开号：US08093394B2

  公开（公告）日：2012-01-10

  The invention relates to new compounds of 5-thioxilose, preferably derivatives of the 5-thioxilopyranose type, and to a method for preparing the same and their use as the active ingredient of drugs mainly intended for treating or inhibiting thrombosis or heart failure or thromboembolic diseases.

  本发明涉及5-硫代木糖的新化合物，优选为5-硫代木糖吡喃糖衍生物，以及其制备方法和它们作为药物的活性成分的用途，主要用于治疗或抑制血栓形成、心力衰竭或血栓栓塞性疾病。
• Compounds derived from 5-thioxylose and their use in therapeutics
  申请人：Laboratories Fournier S.A.

  公开号：US08148407B2

  公开（公告）日：2012-04-03

  The invention relates to novel 5-thioxylose compounds, preferably derivatives of the 5-thioxylopyranose type, to the process for their preparation and to their use as active principles of drugs intended especially for the treatment or prevention of thrombosis or cardiac insufficiency.

  该发明涉及新型5-硫氧木糖化合物，优选为5-硫氧基吡喃木糖衍生物，以及它们的制备过程和作为药物活性成分的用途，特别是用于治疗或预防血栓形成或心脏功能不全的药物。
• NOUVEAUX COMPOSES DERIVES DU 5-THIOXYLOSE ET LEUR UTILISATION THERAPEUTIQUE
  申请人：LABORATOIRES FOURNIER S.A.

  公开号：EP1861411A2

  公开（公告）日：2007-12-05
• DERIVES DE 5 - THIOXYLOPYRANOSE ET LEUR UTILISATION EN THERAPEUTIQUE
  申请人：LABORATOIRES FOURNIER SA

  公开号：EP2066683A1

  公开（公告）日：2009-06-10