PDK1 inhibitor, 7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: PDK1 inhibitor, 7
• 英文别名: 1-[(3,4-difluorophenyl)methyl]-2-oxo-N-[2-[(2-oxo-1,3-dihydrobenzimidazol-5-yl)oxy]-1-phenylethyl]pyridine-3-carboxamide
• 化学式: C₂₈H₂₂F₂N₄O₄
• 分子量: 516.5
• InChiKey: GCWCGSPBENFEPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  99.8
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] 2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE AS DUAL INHIBITORS OF PDK1/AURA<br/>[FR] COMPOSÉS DE 2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE ET LEUR UTILISATION À TITRE D'INHIBITEURS DOUBLES DE PDK1/AURA
  申请人：INTERNATIONAL SOC FOR DRUG DEVELOPMENT S R L

  公开号：WO2017211946A1

  公开（公告）日：2017-12-14

  The present invention concern a 2-oxo-1,2-dihydropyridine-3-carboxamide compound of Formula (I) in the treatment of pathologies which require a dual inhibitor of PDK1/AurA enzymes such as for instance tumours, particularly glioblastoma.

  本发明涉及一种式（I）的2-氧代-1,2-二氢吡啶-3-羧酰胺化合物在需要PDK1/AurA酶的双重抑制剂治疗病理学中的应用，例如肿瘤，特别是胶质母细胞瘤。
• PYRIDINONYL PDK1 INHIBITORS
  申请人：Lind Kenneth Egnard

  公开号：US20100144730A1

  公开（公告）日：2010-06-10

  The present invention provides pyridinonyl PDK1 inhibitors and methods of treating cancer using the same.

  本发明提供了吡啶基PDK1抑制剂及其使用方法，用于治疗癌症。
• 2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE AS DUAL INHIBITORS OF PDK1/AURA
  申请人：International Society for Drug Development S.r.l.

  公开号：EP3468556A1

  公开（公告）日：2019-04-17
• MULTI-STAGE PERSONALIZED LONGEVITY THERAPEUTICS
  申请人：Insilico Medicine, Inc.

  公开号：US20190030078A1

  公开（公告）日：2019-01-31

  A method of treating senescence in a subject can include applying a senoremediation drug treatment protocol to the subject in order to rescue one or more first cells in the subject, wherein the senoremediation drug treatment protocol is derived from a computational transcriptome analysis of the tissue or organ of the subject. The method can include applying a senolytic drug treatment protocol to the subject in order to remove one or more second cells in the subject. The method can include introducing stem cells into a tissue and/or organ of the subject in order to rejuvenate one or more tissue cells in the tissue and/or one or more organ cells in the organ. The method can include carrying out a reinforcement step that includes one or more actions that prevent further senescence or degradation of the tissue or organ.
• US8778977B2
  申请人：——

  公开号：US8778977B2

  公开（公告）日：2014-07-15