2-(1H-1,2,4-triazol-1-yl)-3-(trifluoromethyl)thieno[3,4-b]pyrazine | 1381779-27-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-(1H-1,2,4-triazol-1-yl)-3-(trifluoromethyl)thieno[3,4-b]pyrazine
• 英文别名: 3-(1,2,4-Triazol-1-yl)-2-(trifluoromethyl)thieno[3,4-b]pyrazine
• CAS: 1381779-27-6
• 化学式: C₉H₄F₃N₅S
• 分子量: 271.225
• InChiKey: MHBUZPVLPBDQLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  84.7
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• [EN] SUBSTITUTED THIENO [3,4-B] PYRAZINE COMPOUNDS<br/>[FR] COMPOSÉS PYRAZINE [3,4-B] THIÉNO SUBSTITUÉS
  申请人：LUPIN LTD

  公开号：WO2012076966A1

  公开（公告）日：2012-06-14

  The invention relates to thieno[3,4-b]pyrazine derivatives of Formula (I) and their pharmaceutically acceptable salts thereof, pharmaceutical compositions containing the compounds of the invention. The invention also relates to methods for treating, preventing and/or managing diseases, disorders, syndromes or conditions associated with inadequate insulin secretion such as diabetes, related disorders and metabolic syndrome. The invention also relates to methods for treating, preventing and/or managing diseases, disorders, syndromes or conditions which are affected or facilitated by the modulation of GLP-1 receptor. The invention also relates to processes for the preparation of the compounds of Formula (I).

  该发明涉及Formula (I)的噻吩[3,4-b]吡嗪衍生物及其药用盐，含有该发明化合物的药物组合物。该发明还涉及用于治疗、预防和/或管理与胰岛素分泌不足有关的疾病、紊乱、综合征或疾病，如糖尿病、相关紊乱和代谢综合征的方法。该发明还涉及用于治疗、预防和/或管理受GLP-1受体调节影响或促进的疾病、紊乱、综合征或疾病的方法。该发明还涉及Formula (I)化合物的制备方法。