BHF177 | 917896-43-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: BHF177
• 英文别名: (1R,2R,3R)-bicyclo[2.2.1]hept-2-yl-[2-methyl-5-(4-trifluoromethyl-phenyl)-pyrimidin-4-yl]-amine；4-Pyrimidinamine, N-(1R,2R,4S)-bicyclo(2.2.1)hept-2-yl-2-methyl-5-(4-(trifluoromethyl)phenyl)-；N-[(1R,2R,4S)-2-bicyclo[2.2.1]heptanyl]-2-methyl-5-[4-(trifluoromethyl)phenyl]pyrimidin-4-amine
• CAS: 917896-43-6
• 化学式: C₁₉H₂₀F₃N₃
• 分子量: 347.383
• InChiKey: ADHZHPOKTRHZGT-DXCKQFNASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  37.8
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• PYRIMIDINE DERIVATIVES
  申请人：Floersheim Philipp

  公开号：US20100179127A1

  公开（公告）日：2010-07-15

  The invention relates to novel heterocyclic compounds of the formula in free base form or in acid addition salt form, in which R 1 , R 2 , R 3 , R 4 and A are as defined in the specification, to their preparation, to their use as medicaments and to medicaments comprising them.

  本发明涉及以下式子的新异环化合物，其在自由碱基形式或酸加成盐形式中存在，其中R1，R2，R3，R4和A如规范中所定义，以及它们的制备方法，它们作为药物的用途以及包含它们的药物。
• METHODS OF DELAYING AND TREATING DIABETES
  申请人：Ligon Brooke

  公开号：US20130252886A1

  公开（公告）日：2013-09-26

  The present invention provides methods of treating hyperglycemia and delaying the onset of diabetes, comprising administering to a mammal in need thereof a therapeutically effective amount of a GABA receptor agonist at or near a time of an exogenous insulin administration or a meal.