Cetotiamine hydrochloride monohydrate | 16145-28-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: Cetotiamine hydrochloride monohydrate
• 英文别名: ethyl [(Z)-2-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]-5-ethoxycarbonyloxypent-2-en-3-yl]sulfanylformate;hydrate;hydrochloride
• CAS: 16145-28-1
• 化学式: C18H29ClN4O7S
• 分子量: 481.0
• InChiKey: NRLOCOXPOJIONU-ZABRKXACSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.61
• 重原子数：
  31
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  160
• 氢给体数：
  3
• 氢受体数：
  11

文献信息

• LIGAND REGULATED PROTEIN-PROTEIN INTERACTION SYSTEM
  申请人：ST. ANNA KINDERKREBSFORSCHUNG

  公开号：US20200390813A1

  公开（公告）日：2020-12-17

  A ligand regulated protein-protein interaction system based on a lipocalin-fold molecule including: (a) a lipocalin-fold molecule; (b) a lipocalin-fold ligand with a low molecular weight of 1500 Da or below; and (c) a lipocalin-fold binding interaction partner; wherein the lipocalin-fold molecule can bind to the lipocalin-fold ligand; and wherein the lipocalin-fold molecule bound to the lipocalin-fold ligand binds to the lipocalin-fold binding interaction partner with an affinity which is at least 10-fold higher than the affinity of the lipocalin-fold molecule not bound to the lipocalin-fold ligand; and wherein the lipocalin-fold binding interaction partner is not a naturally occurring protein which has an affinity of <10 μM to any naturally occurring lipocalin-fold molecule in the presence of any lipocalin-fold ligand.
• A GROUP OF CHIMERIC ANTIGEN RECEPTORS (CARS)
  申请人：ST. ANNA KINDERKREBSFORSCHUNG

  公开号：US20210386781A1

  公开（公告）日：2021-12-16

  A group of chimeric antigen receptors (CARs) having two, three or four CAR molecules, wherein the members of the group of CARs can be different in their amino acid sequences, and wherein each of the CAR molecules of the group includes at least a transmembrane domain and an ectodomain comprising either an antigen binding moiety or a binding site to which another polypeptide is able to bind, wherein the polypeptide comprises an antigen binding moiety; wherein each CAR molecule of the group includes at least one dimerization domain, wherein this dimerization of a pair of dimerization domains is either induced by a regulating molecule and optionally reduced by another regulating molecule, or occurs in the absence of a regulating molecule and is reduced by a regulating molecule, and wherein the antigen binding moieties of the CAR molecules of the group specific for one target antigen.
• [EN] COMPOSITION<br/>[FR] COMPOSITION<br/>[JA] 組成物
  申请人：KOWA CO

  公开号：WO2019189714A1

  公开（公告）日：2019-10-03

  クコシを含有する液状又は半固形状の組成物において、沈殿や不溶物の生成を抑制する新たな技術の提供。　次の成分（Ａ）、（Ｂ）及び（Ｃ）： （Ａ）クコシ （Ｂ）アスパラギン酸及びその塩並びにそれらの溶媒和物よりなる群から選ばれる１種以上 （Ｃ）次の成分（Ｃ－１）及び（Ｃ－２）よりなる群から選ばれる１種以上　（Ｃ－１）ビタミンＢ群　（Ｃ－２）ニンニク加工物 を含有する、液状又は半固形状の組成物。