N-(2-chlorophenyl)-9-hydroxy-2-methyl-11-oxo-1-azatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraene-10-carboxamide | 1346530-13-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-chlorophenyl)-9-hydroxy-2-methyl-11-oxo-1-azatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraene-10-carboxamide
• CAS: 1346530-13-9
• 化学式: C₁₉H₁₅ClN₂O₃
• 分子量: 354.793
• InChiKey: IBMOFHCFLKUYPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  69.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  ethyl 6-hydroxy-2-methyl-4-oxo-2,4-dihydro-1H-pyrrolo[3,2,1-ij]quinoline-5-carboxylate 、 邻氯苯胺 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.25h， 以80%的产率得到N-(2-chlorophenyl)-9-hydroxy-2-methyl-11-oxo-1-azatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraene-10-carboxamide
  参考文献：
  名称：

  4-hydroxy-2-quinolones. 197*. The search for novel diuretics amongst halo-substituted 6-hydroxy-2-methyl-4-oxo-1,2-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline-5-carboxylic acid anilides

  摘要：

  A targeted synthesis of a series of halo-substituted 6-hydroxy-2-methyl-4-oxo-1,2-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline-5-carboxylic acid anilides have been carried out. Peculiarites of the H-1 NMR spectra and the results of investigating the diuretic activity of these compounds are discussed.

  DOI：

  10.1007/s10593-011-0842-9

文献信息

• 4-hydroxy-2-quinolones. 197*. The search for novel diuretics amongst halo-substituted 6-hydroxy-2-methyl-4-oxo-1,2-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline-5-carboxylic acid anilides
  作者：I. V. Ukrainets、N. Yu. Golik、A. L. Shemchuk、O. I. Naboka、Yu. V. Voronina、A. V. Turov

  DOI：10.1007/s10593-011-0842-9

  日期：2011.10

  A targeted synthesis of a series of halo-substituted 6-hydroxy-2-methyl-4-oxo-1,2-dihydro-4H-pyrrolo-[3,2,1-ij]quinoline-5-carboxylic acid anilides have been carried out. Peculiarites of the H-1 NMR spectra and the results of investigating the diuretic activity of these compounds are discussed.