Sodium 5,5-diethyl-6-hydroxy-2-oxo-2,5-dihydropyrimidin-4-olate--acetic acid (1/1/1) | 93858-66-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: Sodium 5,5-diethyl-6-hydroxy-2-oxo-2,5-dihydropyrimidin-4-olate--acetic acid (1/1/1)
• 英文别名: sodium;acetic acid;5,5-diethyl-2,6-dioxopyrimidin-4-olate
• CAS: 93858-66-3
• 化学式: C10H15N2NaO5
• 分子量: 266.23
• InChiKey: DBFLLUVTCWGEHP-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -4.08
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  115
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Fusion proteins comprising enzyme replacement therapy enzymes
  申请人：Denali Therapeutics Inc.

  公开号：US10870837B2

  公开（公告）日：2020-12-22

  Provided herein are fusion proteins that comprise an enzyme replacement therapy enzyme and an Fc region, as well as methods of using such proteins to treat a lysosomal storage disorder. Methods for transporting agents across the blood-brain barrier are also provided herein.

  本文提供了由酶替代疗法酶和 Fc 区组成的融合蛋白，以及使用这种蛋白治疗溶酶体贮积症的方法。本文还提供了跨越血脑屏障运输制剂的方法。
• COLD-ACTIVE BETA GALACTOSIDASE, THE PROCESS FOR ITS PREPARATION AND THE USE THEREOF
  申请人：Université de Liège

  公开号：EP1261697B1

  公开（公告）日：2004-07-28
• USE OF SUBSTRATES AS PHARMACOLOGICAL CHAPERONES
  申请人：Amicus Therapeutics, Inc.

  公开号：EP2137204A1

  公开（公告）日：2009-12-30
• FUSION PROTEINS COMPRISING ENZYME REPLACEMENT THERAPY ENZYMES
  申请人：Denali Therapeutics Inc.

  公开号：EP3692070A1

  公开（公告）日：2020-08-12
• Cold-active beta galactosidase, the process for its preparation and the use thereof
  申请人：Gerday Charles

  公开号：US20050196835A1

  公开（公告）日：2005-09-08

  The present invention relates, for example, to an isolated DNA comprising a sequence which encodes a cold-active beta galatosidase that is specific for lactose and has a stable enzymatic activity at a temperature below 8° C. In embodiments of the invention, the DNA is isolated from the psychrophilic bacterium Pseudoalteromonas haloplanktis.