2-[bis(carboxylatomethyl)amino]acetate;hydron;nickel(3+)

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[bis(carboxylatomethyl)amino]acetate;hydron;nickel(3+)
• 化学式: C6H7NNiO6+
• 分子量: 247.82
• InChiKey: ZTDCFXVUXBPHCE-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -5.35
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  124
• 氢给体数：
  1
• 氢受体数：
  7

ADMET

毒理性

• 致癌性证据

A4：无法归类为人类致癌物。/镍，可溶性无机化合物（NOS），作为镍/

A4: Not classifiable as a human carcinogen. /Nickel, soluble inorganic compounds (NOS), as Ni/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

评估：有足够的人类证据表明硫酸镍具有致癌性，以及镍精炼工业中遇到的镍硫化物和氧化物的组合也具有致癌性。关于金属镍和镍合金的人类致癌性证据不足。有充分的实验动物证据表明金属镍、氧化镍、氢氧化镍和结晶镍硫化物具有致癌性。对于镍合金、镍茂、镍碳酰、镍盐、镍砷化物、镍锑化物、镍硒化物和镍碲化物的致癌性，实验动物中的证据有限。对于三氧化二镍、非晶形镍硫化物和钛酸镍的致癌性，实验动物中的证据不足。工作组根据流行病学研究、实验动物致癌性研究以及其他几种相关数据的综合结果，对镍化合物作为一组进行了总体评估，并得到了镍化合物能在靶细胞的关键位点生成镍离子的基本概念的支持。总体评估：镍化合物对人类具有致癌性（第1组）。金属镍可能对人类具有致癌性（第2B组）。/镍化合物/

Evaluation: There is sufficient evidence in humans for the carcinogenicity of nickel sulfate, and of the combinations of nickel sulfides and oxides encountered in the nickel refining industry. There is inadequate evidence in humans for the carcinogenicity of metallic nickel and nickel alloys. There is sufficient evidence in experimental animals for the carcinogenicity of metallic nickel, nickel monoxides, nickel hydroxides and crystalline nickel sulfides. There is limited evidence in experimental animals for the carcinogenicity of nickel alloys, nickelocene, nickel carbonyl, nickel salts, nickel arsenides, nickel antimonide, nickel selenides and nickel telluride. There is inadequate evidence in experimental animals for the carcinogenicity of nickel trioxide, amorphous nickel sulfide and nickel titanate. The Working Group made the overall evaluation on nickel compounds as a group on the basis of the combined results of epidemiological studies, carcinogenicity studies in experimental animals, and several types of other relevant data, supported by the underlying concept that nickel compounds can generate nickel ions at critical sites in their target cells. Overall evaluation: Nickel compounds are carcinogenic to humans (Group 1). Metallic nickel is possibly carcinogenic to humans (Group 2B). /Nickel compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

基本治疗：建立专利气道。如有必要，进行吸痰。观察呼吸不足的迹象，如有必要，协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测休克并视需要进行治疗……监测肺水肿并视情况进行治疗……对于眼睛污染，立即用水冲洗眼睛。在转运过程中，用生理盐水连续冲洗每只眼睛……不要使用催吐剂。对于误食，如果患者能够吞咽，有强烈的呕吐反射，并且不流口水，用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释……/镍及其相关化合物/

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilation if necessary. Administer oxygen by nonrebreather mask at 10 t0 15 L/min. Monitor for shock and treat if necessary ... . Monitor for pulmonary edema and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . /Nickel and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

高级治疗：对于无意识的病人，考虑进行口咽或鼻咽气管插管以控制气道。使用气囊面罩装置的正压通气技术可能有益。监测心率和必要时治疗心律失常。考虑使用药物治疗肺水肿。开始静脉输液，使用5%葡萄糖盐水/生理盐水维持通道，最小流量。如果出现低血容量的迹象，使用乳酸钠林格氏液。对于伴有低血容量迹象的低血压，谨慎给予液体。如果液体量正常但仍有低血压，考虑使用血管加压药。密切观察液体过载的迹象。使用丙美卡因氢氯化物协助眼部冲洗。/镍及其相关化合物/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Consider drug therapy for pulmonary edema ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors for hypotension with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Nickel and related compounds/

来源:Hazardous Substances Data Bank (HSDB)