2-(3-chlorophenyl)-N-methylethanesulfonamide | 1346254-68-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-chlorophenyl)-N-methylethanesulfonamide
• CAS: 1346254-68-9
• 化学式: C₉H₁₂ClNO₂S
• 分子量: 233.719
• InChiKey: YMTRPSNUALITPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-甲基-1-乙烯磺酰胺 、 3-氯苯硼酸 在 acetylacetonatobis(ethylene)rhodium(I) 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 18.0h， 以65%的产率得到2-(3-chlorophenyl)-N-methylethanesulfonamide
  参考文献：
  名称：

  The first examples of rhodium-catalyzed 1,4-conjugate addition reactions of arylboronic acids with ethenesulfonamides

  摘要：

  An unprecedented rhodium-catalyzed 1,4-conjugate addition of arylboronic acids with ethenesulfonamides resulting in the corresponding 2-arylethanesulfonamides is described. The amino substituent, the applied arylboronic acid, the type of Rh-catalyst, and the experimental conditions all affected the reaction outcome. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.08.108

文献信息

• The first examples of rhodium-catalyzed 1,4-conjugate addition reactions of arylboronic acids with ethenesulfonamides
  作者：Hicham Zilaout、Adri van den Hoogenband、Jelle de Vries、Jos H.M. Lange、Jan Willem Terpstra

  DOI：10.1016/j.tetlet.2011.08.108

  日期：2011.11

  An unprecedented rhodium-catalyzed 1,4-conjugate addition of arylboronic acids with ethenesulfonamides resulting in the corresponding 2-arylethanesulfonamides is described. The amino substituent, the applied arylboronic acid, the type of Rh-catalyst, and the experimental conditions all affected the reaction outcome. (C) 2011 Elsevier Ltd. All rights reserved.