2-methylsulfanyl-4-oxo-5,8-dihydro-4H,6H-9-thia-1,4a,7-triaza-fluorene-3,7-dicarboxylic acid 7-ethyl ester | 1293290-68-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-methylsulfanyl-4-oxo-5,8-dihydro-4H,6H-9-thia-1,4a,7-triaza-fluorene-3,7-dicarboxylic acid 7-ethyl ester
• 英文别名: 5-Ethoxycarbonyl-11-methylsulfanyl-13-oxo-8-thia-1,5,10-triazatricyclo[7.4.0.02,7]trideca-2(7),9,11-triene-12-carboxylic acid
• CAS: 1293290-68-2
• 化学式: C₁₄H₁₅N₃O₅S₂
• 分子量: 369.422
• InChiKey: PXSJCRXEOBXMAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  150
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• NOVEL FUSED THIAZOLO AND OXAZOLO PYRIMIDINONES
  申请人：Srivastava Sanjay

  公开号：US20110130414A1

  公开（公告）日：2011-06-02

  The present invention relates to novel compounds, their pharmaceutically acceptable salts, and their isomers, stereoisomers, conformers, tautomers, polymorphs, hydrates and solvates. The present invention also encompasses pharmaceutically acceptable compositions of said compounds and process for preparing novel compounds. The invention further relates to the use of the above-mentioned compounds for the preparation of medicament for use as pharmaceuticals.

  本发明涉及新化合物、其药学上可接受的盐以及其同分异构体、立体异构体、构象异构体、互变异构体、多晶型、水合物和溶剂合物。本发明还涵盖了上述化合物的药学上可接受的组合物以及制备新化合物的方法。该发明还涉及上述化合物用于制备用作药物的药物的用途。
• [EN] FUSED THIAZOLO AND OXAZOLO PYRIMIDINONES<br/>[FR] PYRIMIDINONES THIAZOLO ET OXAZOLO FUSIONNÉES
  申请人：TORRENT PHARMACEUTICALS LTD

  公开号：WO2011045811A1

  公开（公告）日：2011-04-21

  The present invention relates to novel compounds, their pharmaceutically acceptable salts, and their isomers, steroisomers, conformers, tautomers, polymorphs, hydrates and solvates. The present invention also encompasses pharmaceutically acceptable compositions of said compounds and process for preparing novel compounds. The invention further relates to the use of the above-mentioned compounds for the preparation of medicament for use as pharmaceuticals.

  本发明涉及新化合物，其药用盐及其异构体、立体异构体、构象异构体、互变异构体、多型体、水合物和溶剂合物。本发明还涵盖了所述化合物的药用组合物和制备新化合物的方法。该发明还涉及上述化合物用于制备药物用作药物的用途。
• FUSED THIAZOLO AND OXAZOLO PYRIMIDINONES
  申请人：Torrent Pharmaceuticals Limited

  公开号：EP2385948A1

  公开（公告）日：2011-11-16
• US8541430B2
  申请人：——

  公开号：US8541430B2

  公开（公告）日：2013-09-24
• US8822484B2
  申请人：——

  公开号：US8822484B2

  公开（公告）日：2014-09-02