2-Butanone, 3,3-dimethyl-1-(tetrahydro-2-furanyl)- | 1250701-26-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: 2-Butanone, 3,3-dimethyl-1-(tetrahydro-2-furanyl)-
• 英文别名: 3,3-dimethyl-1-(oxolan-2-yl)butan-2-one
• CAS: 1250701-26-8
• 化学式: C₁₀H₁₈O₂
• 分子量: 170.25
• InChiKey: HNENHHGAYOBVDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Substituted Azaspiro(4.5)Decane Derivatives
  申请人：Gruenenthal GmbH

  公开号：US20160016903A1

  公开（公告）日：2016-01-21

  The invention relates to substituted spirocyclic cyclohexane derivatives which have an affinity for the μ opioid receptor and the ORL1 receptor, processes for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.

  这项发明涉及对取代的螺环烷环己烷衍生物，其具有对μ阿片受体和ORL1受体的亲和力，以及其制备方法、含有这些化合物的药物和利用这些化合物制备药物的用途。
• Substituted azaspiro(4.5)decane derivatives
  申请人：Gruenenthal GmbH

  公开号：US10202345B2

  公开（公告）日：2019-02-12

  The invention relates to substituted spirocyclic cyclohexane derivatives which have an affinity for the μ opioid receptor and the ORL1 receptor, processes for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.

  本发明涉及对μ阿片受体和ORL1受体具有亲和力的取代螺环环己烷衍生物、其制备工艺、含有这些化合物的药物以及使用这些化合物制备药物。
• Treprostinil derivatives and compositions and uses thereof
  申请人：CORSAIR PHARMA, INC.

  公开号：US10246403B2

  公开（公告）日：2019-04-02

  The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.

  本公开提供了可作为曲普瑞替尼原药的曲普瑞替尼衍生物。曲普瑞司替尼衍生物可用于治疗任何对曲普瑞司替尼治疗有反应的病症，包括肺动脉高压等肺动脉高压。
• TREPROSTINIL DERIVATIVES AND COMPOSITIONS AND USES THEREOF
  申请人：CORSAIR PHARMA, INC.

  公开号：US20180170855A1

  公开（公告）日：2018-06-21

  The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.