(E)-methyl 2-((1S,3S,7R,11S,15S,17R,21R,23R,25S,E)-17-((R)-1-((benzyloxy)methoxy)ethyl)-21-((tert-butyldiphenylsilyl)oxy)-11-methoxy-10,10,26,26-tetramethyl-5-methylene-12,19-dioxo-25-((triethylsilyl)oxy)-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-13-ylidene)acetate | 1383605-09-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: (E)-methyl 2-((1S,3S,7R,11S,15S,17R,21R,23R,25S,E)-17-((R)-1-((benzyloxy)methoxy)ethyl)-21-((tert-butyldiphenylsilyl)oxy)-11-methoxy-10,10,26,26-tetramethyl-5-methylene-12,19-dioxo-25-((triethylsilyl)oxy)-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-13-ylidene)acetate
• CAS: 1383605-09-1
• 化学式: C₆₆H₉₄O₁₃Si₂
• 分子量: 1151.64
• InChiKey: WFCXSQPEVZZDRW-LDDXQFDUSA-N

物化性质

• 沸点：
  976.8±65.0 °C(predicted)
• 密度：
  1.13±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  (E)-methyl 2-((1S,3S,7R,11S,15S,17R,21R,23R,25S,E)-17-((R)-1-((benzyloxy)methoxy)ethyl)-21-((tert-butyldiphenylsilyl)oxy)-11-methoxy-10,10,26,26-tetramethyl-5-methylene-12,19-dioxo-25-((triethylsilyl)oxy)-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-13-ylidene)acetate 在 cerium(III) chloride heptahydrate 、 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 1.17h， 生成
  参考文献：
  名称：

  Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity

  摘要：

  The role of the C-8 gem-dimethyl group in the A-ring of bryostatin 1 has been examined through chemical synthesis and biological evaluation of a new analogue. Assays for biological function using U937, K562, and MV4-11 cells as well as the profiles for downregulation of PKC isozymes revealed that the presence of this group is not a critical determinant for the unique pattern of biological activity of bryostatin. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.04.073
• 作为产物：
  描述：

  在 吡啶 、 4-二甲氨基吡啶 、 乙酸酐 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以4.6 mg的产率得到(E)-methyl 2-((1S,3S,7R,11S,15S,17R,21R,23R,25S,E)-17-((R)-1-((benzyloxy)methoxy)ethyl)-21-((tert-butyldiphenylsilyl)oxy)-11-methoxy-10,10,26,26-tetramethyl-5-methylene-12,19-dioxo-25-((triethylsilyl)oxy)-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-13-ylidene)acetate
  参考文献：
  名称：

  Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity

  摘要：

  The role of the C-8 gem-dimethyl group in the A-ring of bryostatin 1 has been examined through chemical synthesis and biological evaluation of a new analogue. Assays for biological function using U937, K562, and MV4-11 cells as well as the profiles for downregulation of PKC isozymes revealed that the presence of this group is not a critical determinant for the unique pattern of biological activity of bryostatin. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.04.073