C35-difluorosolamin | 1338560-66-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: C35-difluorosolamin
• 英文别名: (2R)-2-(difluoromethyl)-4-[(13R)-13-hydroxy-13-[(2R,5R)-5-[(1R)-1-hydroxytridecyl]oxolan-2-yl]tridecyl]-2H-furan-5-one
• CAS: 1338560-66-9
• 化学式: C₃₅H₆₂F₂O₅
• 分子量: 600.871
• InChiKey: DYHBJIBXSBCFQD-YKNMHBIISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.3
• 重原子数：
  42
• 可旋转键数：
  27
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  在 氢氟酸 、 水 、 间氯过氧苯甲酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 甲苯 、 乙腈 为溶剂， 生成 C35-difluorosolamin
  参考文献：
  名称：

  Design and synthesis of C35-fluorinated solamins and their growth inhibitory activities against human cancer cell lines

  摘要：

  The convergent synthesis of C35-fluorinated analogues of solamin, a mono-THF Annonaceous acetogenin, has been achieved by the Sonogashira coupling of the THF ring fragment and the fluorinated gamma-lactone fragment. It was revealed that the number of fluorine atoms on the gamma-lactone moiety affects the growth inhibitory activities against human cancer cell lines. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.08.011

文献信息

• Design and synthesis of C35-fluorinated solamins and their growth inhibitory activities against human cancer cell lines
  作者：Naoto Kojima、Yuki Suga、Hiromi Hayashi、Takao Yamori、Takehiko Yoshimitsu、Tetsuaki Tanaka

  DOI：10.1016/j.bmcl.2011.08.011

  日期：2011.10

  The convergent synthesis of C35-fluorinated analogues of solamin, a mono-THF Annonaceous acetogenin, has been achieved by the Sonogashira coupling of the THF ring fragment and the fluorinated gamma-lactone fragment. It was revealed that the number of fluorine atoms on the gamma-lactone moiety affects the growth inhibitory activities against human cancer cell lines. (C) 2011 Elsevier Ltd. All rights reserved.