3-deoxy-5'-O-methylschweinfurthin A | 1353178-56-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3-deoxy-5'-O-methylschweinfurthin A
• 英文别名: (2R,4aR,9aR)-7-[(E)-2-[4-[(2E)-3,7-dimethylocta-2,6-dienyl]-3-hydroxy-5-methoxyphenyl]ethenyl]-1,1,4a-trimethyl-3,4,9,9a-tetrahydro-2H-xanthene-2,5-diol
• CAS: 1353178-56-9
• 化学式: C₃₅H₄₆O₅
• 分子量: 546.747
• InChiKey: ZGLCZWKAIKZIQU-KFNWDQBUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  40
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.49
• 拓扑面积：
  79.2
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (E)-(4-(3,7-dimethylocta-2,6-dien-1-yl)-3-methoxy-5-(methoxymethoxy)phenyl)methanol 在 15-冠醚-5 、 sodium hydride 、 对甲苯磺酸 、 三乙胺 、 sodium iodide 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 丙酮 、 mineral oil 为溶剂， 反应 16.0h， 生成 3-deoxy-5'-O-methylschweinfurthin A
  参考文献：
  名称：

  Relevance of the C-5 position to schweinfurthin induced cytotoxicity

  摘要：

  The schweinfurthins are an intriguing group of anti-proliferative agents that display low nanomolar activities against several cell types, including the human-derived glioblastoma cell line SF-295, but have little impact on other cell lines even at micromolar concentrations. This activity has inspired the synthesis of seven of the natural schweinfurthins, all with the correct absolute stereochemistry, and a variety of analogues designed to probe different facets of the pharmacophore. Reported herein is the synthesis of several new schweinfurthin analogues varied at the C-5 position along with data on their biological activity in the NCI 60 cell-line assay. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.10.034

文献信息

• Relevance of the C-5 position to schweinfurthin induced cytotoxicity
  作者：Joseph J. Topczewski、Michael P. Callahan、John G. Kodet、Jery D. Inbarasu、Nolan R. Mente、John A. Beutler、David F. Wiemer

  DOI：10.1016/j.bmc.2011.10.034

  日期：2011.12

  The schweinfurthins are an intriguing group of anti-proliferative agents that display low nanomolar activities against several cell types, including the human-derived glioblastoma cell line SF-295, but have little impact on other cell lines even at micromolar concentrations. This activity has inspired the synthesis of seven of the natural schweinfurthins, all with the correct absolute stereochemistry, and a variety of analogues designed to probe different facets of the pharmacophore. Reported herein is the synthesis of several new schweinfurthin analogues varied at the C-5 position along with data on their biological activity in the NCI 60 cell-line assay. (C) 2011 Elsevier Ltd. All rights reserved.