(9RS,10SR)-tetramethyl 2,2'-[(1,2,5,6-tetramethoxy-9,10-dihydroanthracene-9,10-diyl)di(methylene)]dimalonate | 1337952-45-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: (9RS,10SR)-tetramethyl 2,2'-[(1,2,5,6-tetramethoxy-9,10-dihydroanthracene-9,10-diyl)di(methylene)]dimalonate
• 英文别名: Tetramethyl 2,2'-((9S,10R)-1,2,5,6-tetramethoxy-9,10-dihydroanthracene-9,10-diyl)bis(methylene)dimalonate；dimethyl 2-[[(9R,10S)-1,2,5,6-tetramethoxy-10-(3-methoxy-2-methoxycarbonyl-3-oxopropyl)-9,10-dihydroanthracen-9-yl]methyl]propanedioate
• CAS: 1337952-45-0
• 化学式: C₃₀H₃₆O₁₂
• 分子量: 588.609
• InChiKey: OHOBIBWNHFVVTC-HDICACEKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  42
• 可旋转键数：
  16
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  142
• 氢给体数：
  0
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  dimethyl 2-(2,3-dimethoxyphenyl)cyclopropane-1,1-dicarboxylate 在 四氯化锡 作用下， 以 硝基甲烷 为溶剂， 反应 3.0h， 生成 (9RS,10SR)-tetramethyl 2,2'-[(1,2,5,6-tetramethoxy-9,10-dihydroanthracene-9,10-diyl)di(methylene)]dimalonate
  参考文献：
  名称：

  (3 + 3)-Cyclodimerization of Donor–Acceptor Cyclopropanes. Three Routes to Six-Membered Rings

  摘要：

  The ability of donor acceptor cyclopropanes to (3 + 3)-cyclodimerize is disclosed. It has been found that Lewis acid-induced transformations of 2-(hetero)arylcyclopropane-1,1-dicarboxylates containing electron-abundant aromatic substituents led to the construction of six-membered cyclic systems. Depending on the substrate properties and the Lewis acid applied, three types of products can be obtained: (1) 1,4-diarylcyclohexanes, (2) 1-aryl-1,2,3,4-tetrahydronaphthalenes, and (3) 9,10-dihydroanthracenes.

  DOI：

  10.1021/jo201612w