(3-(Pyrimidin-4-yl)phenyl)methanol | 1349715-48-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (3-(Pyrimidin-4-yl)phenyl)methanol
• 英文别名: (3-pyrimidin-4-ylphenyl)methanol
• CAS: 1349715-48-5
• 化学式: C₁₁H₁₀N₂O
• 分子量: 186.21
• InChiKey: QBSHNOQPLXWPEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  46
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] 2, 4, 6-TRISUBSTITUTED PYRIMIDINES AS PHOSPHOTIDYLINOSITOL (PI) 3-KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF CANCER<br/>[FR] PYRIMIDINES A SUBSTITUTION TRIPLE AUX POSITIONS 2, 4, 6 UTILISES EN TANT QU'INHIBITEURS DE PHOSPHOTIDYLINOSITOL (PI) 3-KINASE ET UTILISATIONS DE CELLES-CI POUR TRAITER UN CANCER
  申请人：ASTRAZENECA AB

  公开号：WO2006005914A1

  公开（公告）日：2006-01-19

  The invention concerns pyrimidine derivatives of Formula (I) wherein each of p, R1, R2, q, R3, r, R4, X1 and Q1 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the production of an anti-proliferative effect in a warm-blooded animal such as man.

  该发明涉及式（I）中的嘧啶衍生物，其中p、R1、R2、q、R3、r、R4、X1和Q1中的每一个具有描述中定义的任何含义；其制备过程，含有它们的药物组合物以及它们在制造用于在温血动物（如人类）中产生抗增殖效应的药物的用途。
• 2,4,6-TRISUBSTITUTED PYRIMIDINES AS PHOSPHOTIDYLINOSITOL (PI) 3-KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF CANCER
  申请人：AstraZeneca AB

  公开号：EP1768978A1

  公开（公告）日：2007-04-04
• NOVEL IODO PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)-IMPLICATED DISEASES AND CONDITIONS
  申请人：University Of Louisville Research Foundation, Inc.

  公开号：EP2480235A2

  公开（公告）日：2012-08-01
• [EN] NOVEL IODO PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)-IMPLICATED DISEASES AND CONDITIONS<br/>[FR] NOUVEAUX DÉRIVÉS D'IODO PYRIMIDINES UTILES POUR LE TRAITEMENT DE MALADIES OU AFFECTIONS LIÉES AU FACTEUR INHIBITEUR DE LA MIGRATION DES MACROPHAGES
  申请人：UNIV LOUISVILLE RES FOUND

  公开号：WO2011038234A2

  公开（公告）日：2011-03-31

  Compounds useful for the inhibition of macrophage migration inhibitory factor (MIF) are provided herein, having the Formula (I): wherein A is selected from the group consisting of aromatic or non-aromatic rings, bicyclic rings, polycyclic rings, alkenes or alkynes; B is H, OH, OR, SR, NH2, NHR, or alkyl; R is H or alkyl, and X and Y are independently N or CH, but one of X and Y must be N. Also provided are pharmaceutical compositions comprising a Formula I compound and methods for the treatment of MIF-implicated diseases or conditions, comprising administering a safe and effective amount of a Formula I compound.