7-(diethylamino)-N-[2-[[1-(2-nitrophenyl)-3-oxo-3-(pyridin-2-ylmethylamino)propyl]amino]-2-oxoethyl]-2-oxochromene-3-carboxamide | 1236256-13-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-(diethylamino)-N-[2-[[1-(2-nitrophenyl)-3-oxo-3-(pyridin-2-ylmethylamino)propyl]amino]-2-oxoethyl]-2-oxochromene-3-carboxamide
• CAS: 1236256-13-5
• 化学式: C₃₁H₃₂N₆O₇
• 分子量: 600.631
• InChiKey: VBRLRQFAVSXSQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  44
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  176
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  铜 、 7-(diethylamino)-N-[2-[[1-(2-nitrophenyl)-3-oxo-3-(pyridin-2-ylmethylamino)propyl]amino]-2-oxoethyl]-2-oxochromene-3-carboxamide 在 HOCH₂CH₂C₄H₈N₂CH₂CH₂SO₃H 作用下， 以 H₂O 、 dimethylsulfoxide 为溶剂， 生成 、
  参考文献：
  名称：

  Toward the Detection of Cellular Copper(II) by a Light-Activated Fluorescence Increase

  摘要：

  A new type of Cu2+ fluorescent sensor, courage, has been prepared with a photosensitive nitrophenyl group incorporated into the backbone of a coumarin-tagged tetradentate ligand. Coucage provides a selective fluorescence response for Cu2+ over other biologically relevant metal ions. Coordination of Cu2+ dims the fluorescence output until irradiation with UV light cleaves the ligand backbone, which relieves the copper-induced quenching to provide a turn-on response. Experiments in live MCF-7 cells show that coucage can be used for detecting changes in intracellular Cu2+ upon the addition of excess exogenous copper. If improvements can be made to increase its affinity for copper, this new type of turn-on sensor could be used as a tool for visualizing the cellular distribution of labile copper to gain insight into the mechanisms of copper trafficking.

  DOI：

  10.1021/ic1004165

文献信息

• PHOTOLABILE CAGED TRANSITION METAL COMPLEXES AND METHODS OF USING THE SAME
  申请人：Franz Katherine J.

  公开号：US20110184333A1

  公开（公告）日：2011-07-28

  The present invention provides compounds of Formula I: (I) along with compositions comprising the same and methods of using the same, such as for photodynamic therapy in the treatment of cancer.
• US8440827B2
  申请人：——

  公开号：US8440827B2

  公开（公告）日：2013-05-14
• US9365593B2
  申请人：——

  公开号：US9365593B2

  公开（公告）日：2016-06-14